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Regulation of Renal Aquaporins and Sodium Transporters During Vasopressin-Escape in the Rat

  • Carolyn A. Ecelbarger
  • Takashi Murase
  • Søren Nielsen
  • Ying Tian
  • Chung-Lin Chou
  • Beatriz Olson
  • Mark A. Knepper
  • Joseph G. Verbalis

Abstract

Several clinical conditions, e.g., congestive heart failure and cirrhosis are associated with inappropriately elevated vasopressin levels relative to serum osmolality (Bichet et al., 1992). In addition, ectopic production of vasopressin-like substances (usually by tumors) can produce inappropriate antidiuresis. This disorder is known as the Syndrome of Inappropriate Antidiuretic Hormone (vasopressin) secretion (SIADH). As expected, inappropriately elevated plasma vasopressin levels will often result in water retention and hyponatremia. Eventually patients go through a physiological process known as “vasopressin-escape” in which they begin to excrete a higher volume of more dilute urine, despite continually high levels of circulating vasopressin. This escape process helps to reduce water retention and more symptomatic hyponatremia. Until recently little was known about the molecular mechanisms underlying escape.

Keywords

Sodium Transporter Apical Plasma Membrane Distal Convoluted Tubule Epithelial Sodium Channel Vasopressin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bichet DG Kluge R Howard RL and Schrier RW 1992 Hyponatremic states In The Kidney: Physiology and Pathophysiology (D W Seldin and G Giebisch eds) Raven New York p 1727–1751Google Scholar
  2. Burg MB Grantham JJ Abramow M and Orloff J 1966 Preparation and study of fragments of single rabbit nephrons Am J Physiol 210: 12931298PubMedGoogle Scholar
  3. Ecelbarger CA Nielsen S Olson B Murase T Baker E A Knepper MA and Verbalis JG 1997 Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat J Clin Invest 99: 18521863PubMedCrossRefGoogle Scholar
  4. Ecelbarger CA Chou C-L Lee AJ DiGiovanni SR Verbalis JG and Knepper MA 1998 Escape from vasopressin-induced antidiuresis: role of vasopressin resistance of the collecting duct Am J Physiol 214: Fl 161-F1166Google Scholar
  5. Ecelbarger CA Verbalis JG and Knepper MA 1999 Rapid up-regulation of thiazide-sensitive cotransporter and α-ENaC expression in a rat model of vasopressin escape [Abstract] J Am Soc Nephrol 10: 14AGoogle Scholar
  6. Flamion B and Spring KR 1990 Water permeability of apical and basolateral cell membranes of rat inner medullary collecting duct Am J Physiol 259: F986-F999PubMedGoogle Scholar
  7. Kim G-H Masilamani S Turner R Mitchell C Wade JB and Knepper MA 1998 The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein Proc Natl Acad Sci USA 95: 1455214557PubMedCrossRefGoogle Scholar
  8. Masilamani S Kim G-H Mitchell C Wade JB and Knepper MA 1999 Aldosterone-mediated regulation of ENaC α ß and γ subunit proteins in rat kidneyJ Clin Invest 104: R19-R23PubMedCrossRefGoogle Scholar
  9. Murase T Baker EA Tian Y Knepper MA and Verbalis JG 1998 Down-regulation of kidney AVP V2 receptor expression during renal escape from vasopressin-induced antidiuresis [Abstract] J Am Soc Nephrol 9: 23AGoogle Scholar
  10. Nielsen S DiGiovanni SR Christensen EI Knepper MA and Harris HW 1993 Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney Proc Natl Acad SciUSA 90: 166311667Google Scholar
  11. Tian Y Sandberg K Murase T Baker EA Speth RC and Verbalis JG 2000 Vasopressin V2 receptor binding is down-regulated during renal escape from vasopressin-induced antidiuresis Endocrinol 141: 307314CrossRefGoogle Scholar
  12. Verbalis JG 1994 Pathogenesis of hyponatremia in an experimental model of the syndrome of inappropriate antidiuresis Am J Physiol 267: R1617-R1625PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Carolyn A. Ecelbarger
    • 1
    • 3
  • Takashi Murase
    • 1
  • Søren Nielsen
    • 2
  • Ying Tian
    • 1
  • Chung-Lin Chou
    • 3
  • Beatriz Olson
    • 1
  • Mark A. Knepper
    • 3
  • Joseph G. Verbalis
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineGeorgetown UniversityWashingtonUSA
  2. 2.Department of Cell Biology, Institute of AnatomyUniversity of AarhusAarhus CDenmark
  3. 3.Laboratory of Kidney and Electrolyte Metabolism, National HeartLung and Blood Institute, National Institutes of HealthBethesdaUSA

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