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Processes Underlying the Regulation of the Sleep-Wake Cycle

  • Chapter
Circadian Clocks

Part of the book series: Handbook of Behavioral Neurobiology ((HBNE,volume 12))

Abstract

Sleep and waking are the two major functional states which in homeotherms can be unambiguously identified by both behavioral and electrophysiologic criteria. Sleep and waking are closely associated with rest and activity. The circadian rest-activity rhythm is present in organisms in which the usual criteria for sleep and waking cannot be applied (e.g., in invertebrates). In fact, sleep and waking may have evolved from the states of rest and activity whose propensity is modulated by the circadian pacemaker. It has been argued that the emergence of sleep has brought an increased flexibility by loosening the control of the circadian pacemaker over behavior and enabling a need-dependent recovery (Borbély and Neuhaus, 1979). It is in particular the intensity dimension of sleep which can be viewed as allowing sleep to fulfil its putative need-dependent functions without disrupting the circadian sleep-wake rhythm. As will be shown, there is evidence that the circadian and sleep-wakedependent aspects of sleep regulation are based on separate mechanisms.

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Authors and Affiliations

  1. Institute Of Pharmacology, University of Zürich, Zürich, CH-8057, Switzerland

    Alexander A. Borbély, Derk-Jan Dijk, Peter Achermann & Irene Tobler

  2. Center for Chronobiology, University of Surrey, Guilford, GU27XH, UK

    Derk-Jan Dijk

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  1. Alexander A. Borbély
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  3. Peter Achermann
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  4. Irene Tobler
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  1. Northwestern University, Evanston, Illinois, USA

    Joseph S. Takahashi , Fred W. Turek  & Robert Y. Moore ,  & 

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Borbély, A.A., Dijk, DJ., Achermann, P., Tobler, I. (2001). Processes Underlying the Regulation of the Sleep-Wake Cycle. In: Takahashi, J.S., Turek, F.W., Moore, R.Y. (eds) Circadian Clocks. Handbook of Behavioral Neurobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1201-1_18

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