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In Vitro/In Vivo Correlations

  • Chapter
Cutaneous Biometrics

Abstract

While the main function of the skin is to protect an organism against dehydration and external stress, it is more or less permeable to some chemical substances and may allow the permeation of certain drugs for therapeutic purposes. The observation of professional intoxications challenged by this permeability has triggered research in this field. Depending on the type and level of therapeutic activity sought in the drug and excipients used in the formulation, one finds it possible to class the different dermatological preparations into three groups:

  1. 1

    Epidermal preparations: drugs are used to treat the epidermis, and only a superficial penetration limited to the epidermis is designed in order to achieve a local action. This type of application is used, for instance, in cosmetology (e.g., sunscreen preparations) and in therapy in the case of antifungal powders

  2. 2

    Endodermal preparations: penetration of drugs must be deeper and pass through the stratum corneum and attain the dermis without reaching the general circulation, which, e.g., is the case with anti-inflammatory preparations containing corticoids

  3. 3

    Transdermal preparations: in this case, the skin is used as a route of administration for drugs. A local action on the muscle underlying the skin may be achieved. However, as a general rule, a systemic action is achieved after the permeation of drugs in the general circulation: transdermal systems currently represent the most characteristic example. For this case, we will only discuss general bioavailability with respect to the other formulations for which it will only be question of topical availability

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Authors and Affiliations

  1. Biopharmaceutic Department, Faculty of Pharmacy, Auvergne University, 63000, Clermont-Ferrand, France

    Eric Beyssac, J. M. Cardot & C. Bonnabry

Authors
  1. Eric Beyssac
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  2. J. M. Cardot
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  3. C. Bonnabry
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Editor information

Editors and Affiliations

  1. Rheinisch-Westfalisch Tecnische Hochschule, Aachen, Germany

    Doris A. Schwindt

  2. Department of Dermatology, University of California, San Francisco, San Francisco, California, USA

    Howard I. Maibach

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Beyssac, E., Cardot, J.M., Bonnabry, C. (2000). In Vitro/In Vivo Correlations. In: Schwindt, D.A., Maibach, H.I. (eds) Cutaneous Biometrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1199-1_27

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  • DOI: https://doi.org/10.1007/978-1-4615-1199-1_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5437-6

  • Online ISBN: 978-1-4615-1199-1

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