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Measurement in Scleroderma Clinical Trials

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Cutaneous Biometrics

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Abstract

Scleroderma or progressive systemic sclerosis is a chronic fibrosing disease that can involve skin and internal organs. Most interventions intended to modify disease in scleroderma are ineffective. This is different from organ specific drugs that can improve the quality of life in patients with scleroderma, such as the treatment of Raynaud's with calcium channel blockers or proton pump inhibitors used to treat reflux esophagitis. The outcome measurements in scleroderma trials, often include observations of skin involvement, functional status, physical performance (such as grip strength and oral aperture) and assessment of internal organ involvement (including pulmonary, gastrointestinal, renal, and cardiac)

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Authors and Affiliations

  1. Department of Rheumatology, University of Western Ontario, London, ON, N6A 4G5, Canada

    Janet E. Pope

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  1. Janet E. Pope
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  1. Rheinisch-Westfalisch Tecnische Hochschule, Aachen, Germany

    Doris A. Schwindt

  2. Department of Dermatology, University of California, San Francisco, San Francisco, California, USA

    Howard I. Maibach

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© 2000 Springer Science+Business Media New York

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Pope, J.E. (2000). Measurement in Scleroderma Clinical Trials. In: Schwindt, D.A., Maibach, H.I. (eds) Cutaneous Biometrics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1199-1_16

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  • DOI: https://doi.org/10.1007/978-1-4615-1199-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5437-6

  • Online ISBN: 978-1-4615-1199-1

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