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Intestinal Absorption of Fat-Soluble Vitamins

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Intestinal Lipid Metabolism
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Abstract

Vitamins are compounds that are required in small quantities for growth and maintenance of normal cell and organ functions; they are nutrients required primarily by vertebrates and not by lower organisms. Although vitamins may be grouped by their source or function, the most commonly used categorization relates to their chemical solubility, namely, hydrophobicity or hydrophilicity, which is directly associated with absorption processes.

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References

  • Argao, E. A., and Heubi, J. E., 1994, Fat-soluble vitamin deficiency in infants and children, Curr. Opin. Ped.5: 562–566.

    Article  Google Scholar 

  • Avery, G. B., and Fletcher, A. B., 1975, Nutrition, in: Neonatology Pathophysiology and Management in the Newborn (G. B. Avery, ed.), Lippincott, Philadelphia.

    Google Scholar 

  • Baker, H., DeAngelis, B., Baker, E., Khalil, M., and Frank, O., 1996, Human plasma patterns during 14 days ingestion of vitamin E, beta-carotene, ascorbic acid, and their various combinations, J. Amer. Coll. Nutr.15: 159–163.

    CAS  Google Scholar 

  • Bates, C. J., 1995, Vitamin A, Lancet 345: 31–35.

    Article  PubMed  CAS  Google Scholar 

  • Bender, D. A., 1995a, Vitamin A: Retinol and beta-carotene, in: Nutritional Biochemistry of the Vitamins (D. A.Bender, ed.), Cambridge University Press, New York, pp. 19–49.

    Google Scholar 

  • Bender, D. A., 1995b, Vitamin D, in: Nutritional Biochemistry of the Vitamins (D. A. Bender, ed.), Cambridge University Press, New York, pp. 51–85.

    Google Scholar 

  • Bender, D. A., 1995c, Vitamin E: Tocopherols and tocotrienols, in: Nutritional Biochemistry of the Vitamins (D. A. Bender, ed.), Cambridge University Press, New York, pp. 87–105.

    Google Scholar 

  • Bergholtz, C. M., 1992, Safety evaluation of Olestra, a non-absorbed fatlike fat replacement, Crit. Rev. Food Sci.Nutr. 32: 141–146.

    Article  Google Scholar 

  • Bieri, J. G., and Farrell, P. M., 1976, Vitamin E, Vit. Hormone 34: 31–75.

    Article  CAS  Google Scholar 

  • Bikle, D. D., 1994, Role of vitamin D, its metabolites, and analogs in the management of osteoporosis, Rheum.Dis. Clin. N. Am. 20: 759–775.

    CAS  Google Scholar 

  • Booth, S. L., Davidson, K. W., Lichtenstein, A. H., and Sadowski, J. A., 1996, Plasma concentrations of dihydro-vitamin Kl following dietary intake of a hydrogenated vitamin Kl-rich vegetable oil, Lipids 31: 709–713.

    Article  PubMed  CAS  Google Scholar 

  • Cheeseman, K. H., Holley, A. E., Kelly, F. J., Wasil, M., Hughes, L., and Burton, G., 1995, Biokinetics in humans of RRR-alpha-tocopherol: The free phenol, acetate ester, and succinate ester forms of vitamins E, Free Rad.Biol. Med. 19: 591–598.

    Article  PubMed  CAS  Google Scholar 

  • Compston, J. E., Merret, A. L., and Hammett, F. G., 1981, Comparison of the appearance of radiolabeled vitamin D3 and 25-hydroxy-vitamin D3 in the chylomicron fraction of plasma after oral administration in man, Clin.Sci. 60: 241–243.

    PubMed  CAS  Google Scholar 

  • Conly, J. M., Stein, K., Worobetz, L., and Rutledge-Harding, S., 1994, The contribution of vitamin K2 (menaquinones) produced by the intestinal microflora to human nutritional requirements for vitamin K, Am.J. Gastroenterol. 89: 915–923.

    PubMed  CAS  Google Scholar 

  • Dawson-Hughes, B., 1996, Calcium and vitamin D nutritional needs of elderly women, J. Nutr. 126: 1165S–1167S.

    PubMed  CAS  Google Scholar 

  • de Pee, S., and West, C. E., 1996, Dietary carotenoids and their role in combating vitamin A deficiency: A review of the literature, Eur. J. Clin. Nutr. 50: S38–S53.

    Google Scholar 

  • Dimitrov, N. V., Meyer-Leece, C., McMillan, J., Gilliland, D., Perloff, M., and Malone, W., 1996, Plasma -α tocopherol concentrations after supplementation with water- and fat-soluble vitamin E, Am. J. Clin. Nutr.64: 329–335.

    PubMed  CAS  Google Scholar 

  • Drent, M. L., and van der Veen, E. A., 1993, Lipase inhibition: A novel concept in the treatment of obesity, Int. J.Obes. Related Metabol. Disord. 17: 241–244.

    CAS  Google Scholar 

  • Ehrenkranz, R. A., 1980, Vitamin E and the neonate, Am. J. Dis. Child. 134: 1157–1166.

    PubMed  CAS  Google Scholar 

  • Elinder, L. S., Hadell, K., Johansson, J., Molgaard, J., Holme, I., Olsson, A. G., and Walldius, G., 1995, Probucol treatment decreases serum concentrations of diet-derived antioxidants, Arterioscler. Thromb. Vasc. Biol.15: 1057–1063.

    Article  PubMed  CAS  Google Scholar 

  • Fotouhi, N., Meydani, M., Santos, M. S., Meydani, S., Hennekens, C. H., and Gaziano, J. M., 1996, Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term ß-carotene supplementation in men, Am. J. Clin. Nutr. 63: 553–558.

    PubMed  CAS  Google Scholar 

  • Francis, R. M., 1997, Is there a differential response to alfacalcidol and vitamin D in the treatment of osteoporosis? Calcified Tissue Int. 60: 111–114.

    Article  CAS  Google Scholar 

  • Gershoff, S. N., 1995, Nutrition evaluation of dietary fat substitutes, Nutr. Reviews 53: 305–313.

    Article  CAS  Google Scholar 

  • Gerster, H., 1997, Vitamin A: Functions, dietary requirements and safety in humans, Int. J. Vit. Nutr. Res. 67: 71–90.

    CAS  Google Scholar 

  • Gijsbers, B. M. G., Jie, K.-S. G., and Vermeer, C., 1996, Effect of food composition on vitamin K absorption in human volunteers, Br. J. Nutr. 76: 223–229.

    Article  PubMed  CAS  Google Scholar 

  • Hagstrom, J. N., Bovill, E. G., Soll, R. F., Davidson, K. W., and Sadowski, J. A., 1995, The pharmacokinetics and lipoprotein fraction distribution of intramuscular vs. oral vitamin Kl supplementation in women of child-bearing age: Effects on hemostasis, Thromb. Haem. 74: 1486–1490.

    CAS  Google Scholar 

  • Haussler, M. R., Haussler, C. A., Jurutka, P. W., Thompson, P. D., Hsieh, J. C., Remus, L. S., Selznick, S. H., and Whitfield, G. K, 1997, The vitamin D hormone and its nuclear receptor: Molecular actions and disease states. J. Endocrinol. 154 (suppl): S57-S73.

    Google Scholar 

  • Hollander, D., 1973, Vitamin K1 absorption by everted intestinal sacs of the rat, Am. J. Physiol. 225: 360–364.

    PubMed  CAS  Google Scholar 

  • Hollander, D., 1981, Intestinal absorption of vitamins A, E, D, and K, J. Lab Clin Med 97: 449–462.

    PubMed  CAS  Google Scholar 

  • Hollander, D., Muralidhara, K. S., and Rim, E., 1976, Colonic absorption of bacterially synthesized vitamin K2 in the rat, Am. J. Physiol. 230: 251–255.

    PubMed  CAS  Google Scholar 

  • Hollander, D., Rim, E., and Muralidhara, K. S., 1977, Vitamin K1 intestinal absorption in vivo. Influence of lumenal contents on transport, Am. J. Physiol. 232: E69–E74.

    Google Scholar 

  • Huang, H. S., and Goodman, D. S., 1965, Vitamin A and carotenoids. I. Intestinal absorption and metabolism of 14C-labeled vitamin A alcohol and beta carotene in the rat, J. Biol. Chem. 240: 2839–2844.

    PubMed  CAS  Google Scholar 

  • Johnson, E. J., and Russell, R. M., 1992, Distribution of orally administered beta carotene among lipoproteins in healthy men, Am. J. Clin. Nutr. 56:128–135.

    PubMed  CAS  Google Scholar 

  • Johnson, E. J., Krasinski, S. D., Howard, L. J., Alger, S. A., Dutta, S. K., and Russell, R. M., 1992, Evaluation of vitamin A absorption by using oil-soluble and water-miscible vitamin A preparations in normal adults and in patients with gastrointestinal disease, Am. J. Clin. Nutr. 55: 857–864.

    PubMed  CAS  Google Scholar 

  • Kayden, H. J., and Traber, M. G., 1993, Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans, J. Lipid Res. 34: 343–358.

    PubMed  CAS  Google Scholar 

  • Kinyamu, H. K., Gallagher, J. C., Balhorn, K. E., Petranick, K. M., and Rafferty, K. A., 1997, Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes, Am. J. Clin. Nutr. 65: 790–797.

    PubMed  CAS  Google Scholar 

  • Krasinski, S. D., Russell, R. M., Otradovec, C. L., Sadowski, J. A., Hartz, S. C., Jacob, R. A., and McGandy, R. B., 1989, Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, a-tocopherol, and cholesterol among elderly people and young adults: Increased plasma retinyl esters among vitamin A-supplement users, Am. J. Clin. Nutr. 49: 112–120.

    PubMed  CAS  Google Scholar 

  • Lamon-Fava, S., Sadowski, J. A., Davidson, K. W., O’Brien, M. E., McNamara, J. R., and Schaefer, E. J., 1998, Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans, Am. J. Clin. Nutr., submitted for publication.

    Google Scholar 

  • Lee-Kim, Y. C., Meydani, M., Kassarjian, Z., Blumberg, J. B., and Russell, R. M., 1988, Enterohepatic circulation of newly administered a-tocopherol in the rat, Int. J. Vit. Nutr. Res. 58: 284–291.

    CAS  Google Scholar 

  • Linder, M. C., 1991, Nutrition and metabolism of vitamins, in: Nutritional Biochemistry and Metabolism with Clinical Applications (M. C. Linder, ed.), Elsevier, New York, 153–189.

    Google Scholar 

  • Lipsky, J. J., 1994, Nutritional sources of vitamin K, Mayo Clin. Proc. 69: 462–466.

    Article  PubMed  CAS  Google Scholar 

  • Mahan, L. K., and Escott-Stump, S., 1996, Digestion, absorption, transport, and excretion of nutrients. In: Krause’s Food, Nutrition, & Diet Therapy, 9th ed. (L. K. Mahan, S. Escott-Stump, and P. Beyer, eds.), W. B. Saunders, Philadelphia, pp. 3–16.

    Google Scholar 

  • Mathias, P. M., Harries, J. T., and Muller, D. P. R., 1981, The optimization and validation of assays to estimate pancreatic esterase activity using well-characterized micellar solutions of cholesterol oleate and tocopherol acetate, J. Lipid Res. 22: 177–184.

    PubMed  CAS  Google Scholar 

  • Mayes, P. A., 1990, Digestion and absorption, in: Harper’s Biochemistry (R. K. Murray, D. K. Granner, P. A. Mayes, and V. W. Rodwell, eds.), Appleton & Lange, Norwalk, CT, pp. 580–590.

    Google Scholar 

  • Melia, A. T., Koss-Twardy, S. G., and Zhi, J., 1996, The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers, J. Clin. Pharm. 36: 647–653.

    CAS  Google Scholar 

  • Meydani, M., 1995, Vitamin E, Lancet 345: 170–175.

    Article  PubMed  CAS  Google Scholar 

  • Meydani, M., Cohn, J. S., Macauley, J. B., McNamara, J. R., Blumberg, J. B., and Schaefer, E. J., 1989, Postpriandial changes in the plasma concentration of α- and y-tocopherol in human subjects fed a fat-rich meal supplemented with fat-soluble vitamins, J. Nutr. 119: 1252–1258.

    PubMed  CAS  Google Scholar 

  • Meydani, M., Meydani, S. N., and Blumberg, J. B., 1993, Modulation by dietary vitamin E and selenium of clotting whole blood thromboxane A2 and aortic prostacyclin synthesis in rats, J. Nutr. Biochem. 4: 322–326.

    Article  CAS  Google Scholar 

  • Meydani, M., Martin, A., Ribaya-Mercado, J. D., Gong, J., Blumberg, J. B., and Russell, R. M., 1994, ß-Carotene supplementation increases antioxidant capacity of plasma in older women, J. Nutr. 124:2397–2403.

    PubMed  CAS  Google Scholar 

  • Moran, J. R., and Greene, H. L., 1987, Nutritional biochemistry of fat-soluble vitamins, in: Pediatric Nutrition: Theory and Practice (R. J. Grand, J. L. Sutphen, and W. H. Dietz, eds.), Butterworths, Boston, pp. 51–67.

    Google Scholar 

  • Nakamura, T., Takebe, K., Imamura, K., Tando, Y., Yamada, N., Arai, Y., Terada, A., Ishii, M., Kikuchi, H., and Suda, T., 1996, Fat-soluble vitamins in patients with chronic pancreatitis (pancreatitis insufficiency), Acta Gastroenterologica Belgica 59: 10–14.

    CAS  Google Scholar 

  • Olson, J. A., 1994, Vitamin A, retinoids, and carotenoids, in: Modern Nutrition in Health and Disease (M. E. Shils, J. A. Olson and M. Shike, eds.), Lea & Febiger, Philadelphia, pp. 287–307.

    Google Scholar 

  • Parker, R. S., 1996, Absorption, metabolism, and transport of carotenoids, FASEB J. 10: 542–551.

    PubMed  CAS  Google Scholar 

  • Peters, J. C, Lawson, K. D., Middleton, S. J., and Triebwasser, K. C., 1997, Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: Summary, J. Nutr. 127: 1719S–1728S.

    PubMed  CAS  Google Scholar 

  • Reddy, V., and Sivakumar, B., 1972, Studies on vitamin A absorption in children, Ind. Pediatr. 9: 307.

    CAS  Google Scholar 

  • Sato, Y., Arai, H., Miyata, A., Tokita, S., Yamamoto, K., Tanabe, T., and Inoue, K., 1993, Primary structure of α-tocopherol transfer protein from rat liver, J. Biol. Chem. 268: 17705–17710.

    PubMed  CAS  Google Scholar 

  • Schlagheck, T. G., Riccardi, K. A., Zorich, N. L., Torri, S. A., Dugan, L. D., and Peters, J. C, 1997, Olestra dose response on fat-soluble and water-soluble nutrients in humans, J. Nutr. 127: 1646S–1665S.

    PubMed  CAS  Google Scholar 

  • Shearer, M. J., 1995, Vitamin D, Lancet 345: 229–234.

    Article  PubMed  CAS  Google Scholar 

  • Shearer, M. J., Barkhan, P., and Webster, G. R., 1970, Absorption and excretion of an oral dose of tritiated vitamin Kj in man, Br. J. Haemotol. 18: 297–308.

    Article  CAS  Google Scholar 

  • Sivakumar, B., and Reddy, V., 1978, Studies on vitamin A absorption in children, Wld. Rev. Nutr. Diet. 31: 125–129.

    CAS  Google Scholar 

  • Sokoll, L. J., Booth, S. L., O’Brien, M. E., Davidson, K. W., Tsaioun, K. I., and Sadowski, J. A., 1997, Changes in serum osteocalcin, plasma phylloquinone, and urinary g-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects, Am. J. Clin. Nutr. 65: 779–784.

    PubMed  CAS  Google Scholar 

  • Tang, G., Serfaty-Lacrosniere, C., Camilo, M. E., and Russell, R. M., 1996, Gastric acidity influences the blood response to a beta carotene dose in humans, Am. J. Clin. Nutr. 64: 622–626.

    PubMed  CAS  Google Scholar 

  • Thomas, M. G., Sturgess, R. P., and Lombard, M., 1997, The steroid vitamin D3 reduces cell proliferation in human duodenal epithelium, Clin. Sci. 94: 375–377.

    Google Scholar 

  • Thompson, G. R., Lewis, B., and Booth, C. C., 1966, Absorption of vitamin D3-3H in control subjects and patients with intestinal malabsorption, J. Clin. Invest. 45: 94–102.

    Article  PubMed  CAS  Google Scholar 

  • Traber, M. G., and Kayden, H. J., 1989, Preferential incorporation of α-tocopherol vs. -v-tocopherol in human lipoproteins, Am. J. Clin. Nutr. 49: 517–526.

    PubMed  CAS  Google Scholar 

  • Traber, M. G., Schiano, T. D., Steephen, A. C., Kayden, H. J., and Shike, M., 1994, Efficacy of water-soluble vitamin E in the treatment of vitamin E malabsorption in short-bowel syndrome, Am. J. Clin. Nutr. 59: 1270–1274.

    PubMed  CAS  Google Scholar 

  • van Vliet, T., 1996, Absorption of beta-carotene and other carotenoids in humans and animal models, Eur. J. Clin. Nutr. 50: S32–S37.

    Google Scholar 

  • van Vliet, T., van Vlissingen, M. F., van Schaik, F., and van der Berg, H., 1996, Beta-carotene absorption and cleavage in rats affected by the vitamin A concentration in the diet, J. Nutr. 126: 499–508.

    PubMed  Google Scholar 

  • Wang, X.-D., 1994, Absorption and metabolism of beta-carotene, J. Amer. Coll. Nutr. 13: 314–325.

    CAS  Google Scholar 

  • Warwick, W. J., Hansen, L. G., and Sharp, H., 1976, Absorption of vitamin A in patients with cystic fibrosis, Clin. Ped. 15: 807–810.

    Article  CAS  Google Scholar 

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Meydani, M., Martin, K.R. (2001). Intestinal Absorption of Fat-Soluble Vitamins. In: Mansbach, C.M., Tso, P., Kuksis, A. (eds) Intestinal Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1195-3_20

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