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Intestinal Lipid Metabolism pp 235–262Cite as

Regulation of Intestinal Cholesterol Metabolism

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Abstract

The amount of unesterified cholesterol within a mammalian cell is tightly controlled. Cells lack a mechanism to degrade cholesterol and excess accumulation of this sterol will cause cell death. The means by which the cell procures cholesterol, therefore, must be closely regulated. Importantly, however, cholesterol is also required for a multitude of critical cellular functions. Thus, it is vital that the cell maintain an ample and continuous supply of this sterol. For example, cholesterol is necessary for normal membrane structure and function; it is required for cell growth; cholesterol regulates the activities of key enzymes and membrane transport proteins; it is a precursor for vitamins, bile acids, and steroid hormones; and in liver and intestine, it is important for normal lipoprotein synthesis and secretion. This critical balancing act by the cell to have sufficient sterol to function normally but not too much to cause cholesterol excess has implications for the development of atherosclerotic heart and peripheral vascular disease, stroke, and cholelithiasis. Because cholesterol is central to these disease states and, therefore, has an important impact on the general health of a population, the regulation of cholesterol metabolism has been extensively studied.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, 52242

    F. Jeffrey Field

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  1. F. Jeffrey Field
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Editors and Affiliations

  1. University of Tennessee College of Medicine, Memphis, Tennessee

    Charles M. Mansbach II

  2. University of Cincinnati College of Medicine, Cincinnati, Ohio

    Patrick Tso

  3. University of Toronto, Toronto, Ontario, Canada

    Arnis Kuksis

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© 2001 Springer Science+Business Media New York

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Field, F.J. (2001). Regulation of Intestinal Cholesterol Metabolism. In: Mansbach, C.M., Tso, P., Kuksis, A. (eds) Intestinal Lipid Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1195-3_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1195-3_13

  • Publisher Name: Springer, Boston, MA

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