The Low-HDL Syndrome: Epidemiology and Pathophysiology

  • Guido Franceschini
  • Barbara Villa
  • Monica Gomaraschi
  • Laura Calabresi
Part of the Medical Science Symposia Series book series (MSSS, volume 18)

Abstract

Fifty years ago, Barr et al. [1] noted that concentrations of high density lipoprotein cholesterol (HDL-C) were lower in patients with coronary heart disease (CHD) than in healthy men. Fifteen years later, Gofman et al. used an analytical ultracentrifuge to separate the plasma lipoprotein fractions, and showed that patients who developed CHD had low levels of HDL-C [2], but HDL-C was largely forgotten until the appearance of Miller and Miller’s seminal publication in 1975 [3]. The Framingham Heart Study and other prospective studies confirmed the association between HDL-C and cardiovascular risk and, during the 1980s, HDL-C attracted a great deal of attention. In the 1990s the results of the statin trials have shifted the focus almost exclusively to low density lipoprotein cholesterol (LDL-C), and to the great benefit of LDL-C lowering in preventing the development of major coronary events in both primary and secondary prevention [4]. However, following the publication of the Veterans Affairs-High Density Lipoprotein Intervention Trial, which shows that raising HDL-C with gemfibrozil leads to a significant reduction of CHD events [5], HDL-C is again assuming considerable importance in the prevention and treatment of CHD. This review discusses the epidemiological and biochemical evidence for low HDL-C as a risk factor for CHD.

Keywords

Cholesterol Obesity Statin Triglyceride Hydroperoxide 

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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Guido Franceschini
  • Barbara Villa
  • Monica Gomaraschi
  • Laura Calabresi

There are no affiliations available

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