Peroxisome Proliferator Activated Receptor Alpha Coordinates Intermediary Metabolism During Fasting

  • Sander Kersten
  • Béatrice Desvergne
  • Walter Wahli
Part of the Medical Science Symposia Series book series (MSSS, volume 18)


In response to repeated and long-lasting food shortages during evolution, humans have evolved with an intricate metabolic control system that allows them to survive prolonged period of food deprivation. One hallmark of this adaptive system is the ability to store large amounts of energy in the form of fat in times of plenty and mobilize this energy under conditions of food shortage such as fasting.


Fatty Acid Oxidation Null Mouse Amino Acid Metabolism Fatty Acid Binding Peroxisome Proliferator Activate Receptor Alpha 
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  1. 1.
    Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature 2000; 405:421–24.PubMedCrossRefGoogle Scholar
  2. 2.
    Lemberger T, Saladin R, Vazquez M, et al. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J Biol Chem 1996;271:1764–69.PubMedCrossRefGoogle Scholar
  3. 3.
    Aoyama T, Peters JM, Iritani N, et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 1998;273:5678–84.PubMedCrossRefGoogle Scholar
  4. 4.
    Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999;103:1489–98.PubMedCrossRefGoogle Scholar
  5. 5.
    Leone TC, Weinheimer CJ, Kelly DP A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 1999;96: 7473–78.PubMedCrossRefGoogle Scholar
  6. 6.
    Le May C, Pineau T, Bigot K, Kohl C, Girard J, Pegorier J-P. Reduced hepatic fatty acid oxidation in fasting PPARa null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression. FEBS Letters 2000;475:163–66.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Sander Kersten
  • Béatrice Desvergne
  • Walter Wahli

There are no affiliations available

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