Skip to main content

Transcranial Magnetic Stimulation and the Study of Cognition

  • Chapter
Experimental Methods in Neuropsychology

Part of the book series: Neuropsychology and Cognition ((NPCO,volume 21))

Abstract

In the past decades, neuroimaging techniques such as computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), magneto-encephalography (MEG) and electro-encephalography (EEG) have shaped the way in which we model behavior. Anatomical neuroimaging techniques have produced ever more detailed descriptions of the extent of lesions produced by brain injury. Functional neuroimaging methods have revealed associations between various behaviors and patterns of activity in cortical and subcortical structures. Functional MRI and PET can inform us about the location of a brain activity associated with a function, while event related potentials using EEG or MEG can provide information about the timing of a brain activation during a task. Careful design of neuroimaging experiments may allow us to conclude with reasonable certainty that the correlation of brain activity with behavior is likely to be due to a causal connection (i.e. that the brain activity produces the behavior). Nevertheless, imaging alone can never provide proof of that assertion. Transcranial magnetic stimulation (TMS) is the only non-invasive technique available that allows us to interfere actively with brain function, and thus investigate the relationship between focal cortical activity and behavior, trace the timing at which a cortical region contributes to a given task, and map the functional connectivity between brain regions (Pascual-Leone et al. 1999a,b, 2000; Walsh and Rushworth, 1999; Walsh and Cowey, 2000).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguggia, M., Zibetti, M., Febbaro, A., Mutani, R. “Transcranial magnetic stimulation in migraine with aura: further evidence of occipital cortex excitability.” Cephalalgia 19 (1999): 465. Abstract.

    Google Scholar 

  • Amassian, V.E., Cracco, R.Q., Maccabee, P.J., Cracco, J.B., Rudell, A.P., Eberle, L. “Suppression of visual perception by magnetic coil stimulation of human occipital cortex.” Electroencephalography and Clinical Neurophysiology 74 (1989): 458–462.

    Article  PubMed  Google Scholar 

  • Amassian, V.E., Cracco, R.Q., Maccabee, P.J., Cracco, J.B., Rudell, A.P., Eberle, L. “Transcranial magnetic stimulation in study of the visual pathway.” Journal of Clinical Neurophysiology 15 (1998): 288–304.

    Article  PubMed  Google Scholar 

  • Aurora, S.K., Ahmad, B.K., Welch, K.M., Bhardhwaj, P., Ramadan, N.M. “Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine.” Neurology 50 (1998): 1111–1114.

    Article  PubMed  Google Scholar 

  • Barbur, J.L., Watson, J.D., Frackowiak, R.S., Zeki, S. “Conscious visual perception without V1.” Brain 116(1993): 1293–302.

    Article  PubMed  Google Scholar 

  • Bartres-Faz, D., Pujol, J., Deus, J., Tormos, J.M., Keenan, J., Pascual-Leone, A. “Identification of brain areas from which TMS induces speech arrest in normal subjects.” Neuroimage 9 (1999): S1051.

    Google Scholar 

  • Beckers, G., Hömberg, V. “Cerebral visual motion blindness: transitory akinetopsia induced by transcranial magnetic stimulation of human area V5.” Proceedings of the Royal Society of London Biological Sciences 249 (1992): 173–178.

    Article  Google Scholar 

  • Berardelli, A., Inghilleri, M., Rothwell, J.C., Romeo, S., Curra, A., Gilio, F., Modugno, N., Manfredi, M. “Facilitation of muscle evoked responses after repetitive cortical stimulation in man.” Experimental Brain Research 122 (1998): 79–84.

    Article  Google Scholar 

  • Chen, R., Classen, J., Gerloff, C, Celnik, P., Wassermann, E.M., Hallett, M., Cohen, L.G. “Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation.” Neurology 48 (1997): 1398–1403.

    Article  PubMed  Google Scholar 

  • Claus, D., Weis, M., Treig, T., Lang, C., Eichhorn, K.F., Sembach, O. “Influence of repetitive magnetic stimuli on verbal comprehension.” Journal of Neurology 240 (1993): 149–150.

    Article  PubMed  Google Scholar 

  • Cohen, L.G., Bandinelli, S., Sato, S., Kufta, C., Hallett, M. “Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation.” Electroencephalography and Clinical Neurophysiology 81 (1991): 366–376.

    Article  PubMed  Google Scholar 

  • Corthout, E., Uttl, B., Walsh, V., Hallett, M., Cowey, A. “Timing of activity in early visual cortex as revealed by transcranial magnetic stimulation.” Neuroreport 20 (1999a): 2631–2634.

    Article  Google Scholar 

  • Corthout, E., Uttl, B., Ziemann, U., Cowey, A., Hallett, M. “Two periods of processing in (circum)striate visual cortex as revealed by transcranial magnetic stimulation.” Neuropsychologia 37 (1999b): 137–145.

    Article  Google Scholar 

  • Cowey, A., Walsh, V. “Magnetically induced phosphenes in sighted, blind and blindsighted observers.” Neuroreport 11 (2000): 3269–3273.

    Article  PubMed  Google Scholar 

  • Day, B.L., Rothwell, J.C., Thompson, P.D., Maertens de Noordhout, A., Nakashima, K., Shannon, K., Marsden, CD. “Delay in the execution of voluntary movement by electrical or magnetic brain stimulation in intact man. Evidence for the storage of motor programs in the brain.” Brain 112 (1989): 649–663.

    Article  PubMed  Google Scholar 

  • Düzel, E., Hufnagel, A., Helmstaedter, C., Elger, C. “Verbal working memory components can be selectively influenced by transcranial magnetic stimulation in patients with left temporal lobe epilepsy.” Neuropsychologia 34 (1996): 775–783.

    Article  PubMed  Google Scholar 

  • Epstein, C.M., Lah, J.K., Meador, K., Weissman, J.D., Gaitan, L.E., Dihenia, B. “Optimum stimulus parameters for lateralized suppression of speech with magnetic brain stimulation.” Neurology 47 (1996a): 1590–1593.

    Article  Google Scholar 

  • Epstein, C.M., Meador, K., Weissman, J.D., Puhalovich, F., Lah, J. J., Gaitan, L.E., Sheppard, S., Davey, K.R. “Localization of speech arrest with transcranial magnetic brain stimulation.” Journal of Clinical Neurophysiology 13 (1996b): 387–390.

    Google Scholar 

  • Epstein, C.M., Zangaladze, A. “Magnetic coil suppression of extrafoveal visual perception using disappearance targets.” Journal of Clinical Neurophysiology 13 (1996c): 242–246.

    Article  PubMed  Google Scholar 

  • Epstein, C.M., Meador, K., Loring, D.W., Wright, R.J., Weissman, J.D., Sheppard, S., Lah, J.J., Puhalovich, F., Gaitan, L., Davey, K.R. “Localization and characterization of speech arrest during transcranial magnetic stimulation.” Clinical Neurophysiology 110 (1999): 1073–1079.

    Article  PubMed  Google Scholar 

  • Epstein, C.M., Woodard, J.L., Stringer, A.Y., Bakay, R.A., Henry, T.R., Pennell, P.B., Litt, B. “Repetitive transcranial magnetic stimulation does not replicate the Wada test.” Neurology 55 (2000): 1025–1027.

    Article  PubMed  Google Scholar 

  • Flitman, S.S., Grafman, J., Wassermann, E.M., Cooper, V., O’Grady, J., Pascual-Leone, A., Hallett, M. “Linguistic processing during repetitive transcranial magnetic stimulation.” Neurology 50 (1998): 175–181.

    Article  PubMed  Google Scholar 

  • Grafman, J., Pascual-Leone, A., Alway, D., Nichelli, P., Gomez-Tortosa, E., Hallett, M. “Induction of a recall deficit by rapid-rate transcranial magnetic stimulation.” Neuroreport 5 (1994): 1157–1160.

    Article  PubMed  Google Scholar 

  • Gugino, L.D., Romero, J.R., Aglio, L., Titone, D., Ramirez, M., Pascual-Leone, A., Grimson, E., Weisenfeld, N., Kikinis, R., Shenton, M.E. “Transcranial magnetic stimulation coregistered with MRI: a comparison of a guided versus blind stimulation technique and its effect on evoked compound muscle action potentials.” Journal of Clinical Neurophysiology 112 (2001): 1781–92.

    Article  Google Scholar 

  • Hallett, M., Wassermann, E.M., Pascual-Leone, A., Valls-Sole, J. “Repetitive transcranial magnetic stimulation. The International Federation of Clinical Neurophysiology.” Electroencephalography and Clinical Neurophysiology Supplement 52 (1999): 105–113.

    Google Scholar 

  • Herwig, U., Padberg, F., Unger, J., Spitzer, M., Schonfeldt-Lecuona, C. “Transcranial magnetic stimulation in therapy studies: examination of the reliability of “standard” coil positioning by neuronavigation.” Biological Psychiatry 50 (2001): 58–61.

    Article  PubMed  Google Scholar 

  • Hilgetag C.C., Théoret, H., Pascual-Leone, A. “Enhanced visual spatial attention ipsilateral to rTMS-induced ‘virtual lesions’ of human parietal cortex.” Nature Neuroscience 4 (2001): 953–957.

    Article  PubMed  Google Scholar 

  • Jennum, P., Friberg, L., Fuglsang-Frederiksen, A., Dam, M. “Speech localization using repetitive transcranial magnetic stimulation.” Neurology 44 (1994): 269–273.

    Article  PubMed  Google Scholar 

  • Kamitani, Y., Shimojo, S. “Manifestation of scotomas created by transcranial magnetic stimulation of human visual cortex.” Nature Neuroscience 2 (1999): 767–771.

    Article  PubMed  Google Scholar 

  • Kammer, T. “Phosphenes and transient scotomas induced by magnetic stimulation of the occipital lobe: their topographic relationship.” Neuropsychologia 31 (1999): 191–198.

    Google Scholar 

  • Kastner, S., Demmer, I., Ziemann, U. “Transient visual field defects induced by transcranial magnetic stimulation over human occipital pole.” Experimental Brain Research 118 (1998): 19–26.

    Article  Google Scholar 

  • Kosslyn, S.M., Pascual-Leone, A., Felician, O., Camposano, S., Keenan, J.P., Thompson, W.L., Ganis, G., Sukel, K.E., Alpert, N.M. “The role of area 17 in visual imagery: convergent evidence from PET and rTMS.” Science 284 (1999): 167–70.

    Article  PubMed  Google Scholar 

  • Lamme, V.A., Super, H., Spekreijse, H. “Feedforward, horizontal, and feedback processing in the visual cortex.” Current Opinion in Neurobiology 8 (1998): 529–35.

    Article  PubMed  Google Scholar 

  • Lomber, S.G., Payne, B.R. “Assessment of neural function with reversible deactivation methods.” Journal of Neuroscience Methods 86 (1999): 105–108.

    Article  Google Scholar 

  • Lomber, S.G., Payne, B.R. “Removal of 2 halves restores the whole — reversal of visual hemineglect during bilateral cortical or collicular inactivation in the cat.” Visual Neuroscience 13 (1996): 1143–1156.

    Article  PubMed  Google Scholar 

  • Maeda, F., Keenan, J.P., Tormos, J.M., Topka, H., Pascual-Leone, A. “Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation.” Clinical Neurophysiology 111 (2000): 800–805.

    Article  PubMed  Google Scholar 

  • Masur, H., Papke, K., Oberwittler, C. “Suppression of visual perception by transcranial magnetic stimulation-experimental findings in healthy subjects and patients with optic neuritis.” Electroencephalography and Clinical Neurophysiology 86 (1993): 259–267.

    Article  PubMed  Google Scholar 

  • Meyer, B.U., Britton, T.C., Kloten, H., Steinmetz, H., Benecke, R. “Coil placement in magnetic brain stimulation related to skull and brain anatomy.” Electroencephalography and Clinical Neurophysiology 81 (1991): 38–46.

    Article  PubMed  Google Scholar 

  • Michelucci, R., Valzania, F., Passarelli, D., Santangelo, M., Rizzi, R., Buzzi, A.M., Tempestini, A., Tassinari, C.A. “Rapid-rate transcranial magnetic stimulation and hemispheric language dominance: usefulness and safety in epilepsy.” Neurology 44 (1994): 1697–1700.

    Article  PubMed  Google Scholar 

  • Miller, M.B., Fendrich, R., Eliassen, J.C., Demirel, S., Gazzaniga, M.S. “Transcranial magnetic stimulation: delays in visual suppression due to luminance changes.” Neuroreport 7 (1996): 1740–1744.

    Article  PubMed  Google Scholar 

  • Mottaghy, F., Gangitano, M., Sparing, R., Krause, B., Pascual-Leone, A. “Segregation of areas related to visual working memory in the prefrontal cortex revealed by rTMS.” Cerebral Cortex 12 (2002): 369–375.

    Article  PubMed  Google Scholar 

  • Mottaghy, F.M., Hungs, M., Brugmann, M., Sparing, R., Boroojerdi, B., Foltys, H., Huber, W., Topper, R. “Facilitation of picture naming after repetitive transcranial magnetic stimulation.” Neurology 10 (1999): 1806–1812.

    Article  Google Scholar 

  • Mottaghy, F.M., Krause, B.J., Kemna, L.J., Töpper, R., Tellmann, L, Beu, M., Pascual-Leone, A., Müller-Gärtner HW. “Modulation of the neural circuitry subserving verbal working memory by repetitive transcranial magnetic stimulation.” Neuroscience Letters 280 (2000): 167–170.

    Article  PubMed  Google Scholar 

  • Mull, B.R., Seyal, M. “Transcranial magnetic stimulation of left prefrontal cortex impairs working memory.” Clinica Neurophysiology 112 (2001): 1672–1675.

    Article  Google Scholar 

  • Mulleners, W.M., Chronicle, E.P., Palmer, J.E., Koehler, P.J., Vredeveld, J.W. “Suppression of perception in migraine: evidence for reduced inhibition in the visual cortex.” Neurology 56 (2001): 178–283.

    Article  PubMed  Google Scholar 

  • Oliven, M., Rossini, P.M., Pasqualetti, P., Traversa, R., Cicinelli, P., Palmieri, M.G., Tomaiuolo, T., Caltagirone, C. “Interhemispheric asymmetries in the perception of unimanual and bimanual cutaneous stimuli. A study using transcranial magnetic stimulation.” Brain 122 (1999a): 1721–1729.

    Article  Google Scholar 

  • Oliveri, M., Rossini, P.M., Traversa, R., Cicinelli, P., Filippi, M.M., Pasqualetti, P., Tomaiuolo, T., Caltagirone, C. “Left frontal transcranial magnetic stimulation reduces contralesional extinction in patients with unilateral right brain damage.” Brain 122 (1999b): 1731–1739.

    Article  Google Scholar 

  • Oliveri, M., Turriziani, P., Carlesimo, G.A., Koch, G., Tomaiuolo, F., Panella, M., Caltagirone, C. “Parieto-frontal interactions in visual-object and visual-spatial working memory: evidence from transcranial magnetic stimulation.” Cerebral Cortex 11 (2001): 606–618.

    Article  PubMed  Google Scholar 

  • Pascual-Leone, A., Gates, J.R., Dhuna, A. “Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation.” Neurology 41 (1991): 697–702.

    Article  PubMed  Google Scholar 

  • Pascual-Leone, A., Valls-Sole, J., Wassermann, E.M., Hallett, M. “Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex.” Brain 117 (1994a): 847–858..

    Article  Google Scholar 

  • Pascual-Leone, A., Gomez-Tortosa E., Grafman, J, Alway, D., Nichelli, P., Hallett, M. “Induction of visual extinction by rapid-rate transcranial magnetic stimulation of parietal lobe.” Neurology 44 (1994b): 494–498.

    Article  Google Scholar 

  • Pascual-Leone, A., Tormos, J.M., Keenan, J., Tarazona, F., Canete, C., Catala, M.D. “Study and modulation of human cortical excitability with transcranial magnetic stimulation.” Journal of Clinical Neurophysiology 15 (1998): 333–343.

    Article  PubMed  Google Scholar 

  • Pascual-Leone, A., Bartres-Faz, D., Keenan, J.P. “Transcranial magnetic stimulation: studying the brain-behaviour relationship by induction of ‘virtual lesions’.” Philosophical Transcripts of Royal Society of London Biological Sciences 354 (1999a): 1229–1238

    Article  Google Scholar 

  • Pascual-Leone, A., Tarazona, F., Keenan, J.P., Tormos, J.M., Hamilton, R., Catala, M.D. “Transcranial magnetic stimulation and neuroplasticity.” Neuropsychologia 37 (1999b): 207–217.

    Article  Google Scholar 

  • Pascual-Leone, A., Walsh, V., Rothwell, J. “Transcranial magnetic stimulation in cognitive neuroscience — virtual lesion, chronometry, and functional connectivity.” Current Opinion in Neurobiology 10 (2000): 232–237.

    Article  PubMed  Google Scholar 

  • Pascual-Leone, A., Walsh, V. “Fast backprojections from the motion area to the primary visual area necessary for visual awareness.” Science 292 (2001): 510–512.

    Article  PubMed  Google Scholar 

  • Paus, T. “Imaging the brain before, during, and after transcranial magnetic stimulation.” Neuropsychologia 37 (1999): 219–224.

    Article  PubMed  Google Scholar 

  • Ray, P.G., Meador, K.J., Epstein, C.M., Loring, D.W., Day, L.J. “Magnetic Stimulation of visual cortex: factors influencing the perception of phosphenes.” Journal of Clinical Neurophysiology 15 (1998): 351–7.

    Article  PubMed  Google Scholar 

  • Robertson, E.M., Tormos, J.M., Maeda, F., Pascual-Leone, A. “The role of the dorsolateral prefrontal cortex during sequence learning is specific for spatial information.” Cerebral Cortex 11 (2001). 628–635.

    Article  PubMed  Google Scholar 

  • Rossi, S., Cappa, S.F., Babiloni, C., Pasqualetti, P., Miniussi, C, Carducci, F., Babiloni, F., Rossini, P.M. “Prefontal cortex in long-term memory: an “interference” approach using magnetic stimulation.” Nature Neuroscience 4 (2001): 948–952.

    Article  PubMed  Google Scholar 

  • Shapiro, K., Pascual-Leone, A., Mottaghy, F.M., Gangitano, M., Caramazza, A. “Grammatical distinctions in the left frontal cortex.” Journal of Cognitive Neuroscience 13 (2001): 713–720.

    Article  PubMed  Google Scholar 

  • Stewart, L., Battelli, L., Walsh, V., Cowey, A. “Motion perception and perceptual learning studied by magnetic stimulation.” EEG Supplement 51 (1999): 334–350.

    Google Scholar 

  • Stewart, L., Walsh, V., Frith, U., Rothwell, J.C. “TMS produces two dissociable types of speech disruption.” Neuroimage 13 (2001): 472–478.

    Article  PubMed  Google Scholar 

  • Stoerig, P., Cowey, A. “Blindsight in man and monkey.” Brain 120 (1997): 535–59.

    Article  PubMed  Google Scholar 

  • Topper, R., Mottaghy, F.M., Brugmann, M., Noth, J., Huber, W. “Facilitation of picture naming by focal transcranial magnetic stimulation of Wernicke’s area.” Experimental Brain Research 121 (1998): 371–378.

    Article  Google Scholar 

  • Tokimura, H., Tokimura, Y., Oliviero, A., Asakura, T., Rothwell, J.C. “Speech-induced changes in corticospinal excitability.” Annals of Neurology 40 (1996): 628–634.

    Article  PubMed  Google Scholar 

  • Walsh, V., Cowey, A. “Transcranial magnetic stimulation and cognitive neuroscience.” Nature Reviews Neuroscience 1 (2000): 73–79.

    Article  PubMed  Google Scholar 

  • Walsh, V., Rushworth, M. “A primer of magnetic stimulation as a tool for neuropsychology.” Neuropsychologia 37 (1999): 125–135.

    PubMed  Google Scholar 

  • Wassermann, E.M., Blaxton, T.A., Hoffman, E.A., Berry, C.D., Oletsky, H., Pascual-Leone, A., Theodore, W.H “Repetitive transcranial magnetic stimulation of the dominant hemisphere can disrupt visual naming in temporal lobe epilepsy patients.” Neuropsychologia 37 (1999): 537–544.

    Article  PubMed  Google Scholar 

  • Wassermann, E.M., Grafman, J., Berry, C., Hollnagel, C., Wild, K., Clark, K., Hallett, M. “Use and safety of a new repetitive transcranial magnetic stimulator.” Electroencephalography and Clinical Neurophysiology 101 (1996): 412–417.

    PubMed  Google Scholar 

  • Weiszkrantz, L. Consciousness lost and found. A neuropsychological exploration. Oxford: Oxford University Press, 1997.

    Google Scholar 

  • Zeki, S. “Localization and globalization in conscious vision.” Annual Review of Neuroscience 24 (2001): 57–86.

    Article  PubMed  Google Scholar 

  • Zeki, S., Bartels, A. “Toward a theory of visual consciousness.” Consciousness and Cognition 8 (1999): 225–259.

    Article  PubMed  Google Scholar 

  • Zeki, S., Ffytche, D.H. “The Riddoch syndrome: insights into the neurobiology of conscious vision.” Brain 121 (1998): 25–45.

    Article  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Théoret, H., Pascual-Leone, A. (2003). Transcranial Magnetic Stimulation and the Study of Cognition. In: Hugdahl, K. (eds) Experimental Methods in Neuropsychology. Neuropsychology and Cognition, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1163-2_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-1163-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5423-9

  • Online ISBN: 978-1-4615-1163-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics