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Androgen Receptor Interacting Proteins: Co-Activators And Co-Repressors

  • Cynthia A. Heinlein
  • Erik R. Sampson
  • Chang Chawnshang 

Abstract

Androgens play critical roles in male sexual differentiation, pubertal sexual maturation, the maintenance of spermatogenesis, and male gonadotropin regulation (Keller et al., 1996; McLachlan et al., 1996; Roy et al., 1999; Sheckter et al., 1989). The androgen receptor (AR), a 110-kDa ligand-inducible transcription factor, mediates androgen signaling by binding to androgen response elements (ARE) within the promoters of target genes (Chang et al., 1988a; Chang et al., 1988b; Lubahn et al., 1988; Tilley et al., 1989; Trapman et al., 1988). Mutations of AR that alter its ability to bind androgens, or alter its transcriptional activity after ligand binding, may result in male infertility, or complete or partial androgen insensitivity (De Bellis et al., 1994; Gottlieb et al, 2001; Mowszowicz et al., 1993; Quigley et al., 1995; Tyagi et al., 1998). Somatic AR mutations have also been identified in some prostate tumors (Bentel and Tilley, 1996).

Keywords

Androgen Receptor Focal Adhesion Kinase Androgen Receptor Protein Steroid Receptor Coactivator Human Androgen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Cynthia A. Heinlein
    • 1
  • Erik R. Sampson
    • 1
  • Chang Chawnshang 
    • 1
  1. 1.George Whipple Lab for Cancer Research, Departments of Pathology, Urology, and Radiation OncologyUniversity of RochesterRochester

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