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Androgens and Coronary Artery Disease

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Androgens and Androgen Receptor

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Abstract

Male gender is one of the classic risk factors for coronary artery disease (CAD) and average life expectancy is some 8 years less in males than females. Androgens or the lack of estrogens have often been regarded as the proximate cause underlying this male disadvantage. With the prospects of much wider therapeutic applications of androgens (contraception, treatment of patients with aplastic anaemia or sarcopenic, osteopenic and dysphoric states, and chronic systemic conditions, as well as an agent against physiological ageing), an important question is whether androgen treatment might increase the risk or severity of CAD. This review is a condensed version of another one (Wu and von Eckardstein, 2002) and addresses six questions: 1. Do observational studies provide any evidence for associations between serum levels of endogenous androgens and CAD endpoints such as myocardial infarction, angina pectoris, and angiographic assessment of atherosclerosis? 2. Which effects on coronary endpoints or symptoms are exerted by application of exogenous testosterone (T) or suppression of endogenous T? 3. What can be learned from animal studies of the effects of androgens on atherosclerosis? 4. How do androgens (and indirectly estrogens) impact on cardiovascular risk factors? 5. How do androgens influence the function of vascular cells pertinent to the pathogenesis of atherosclerosis?

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References

  • Adams, M.R., Williams, J.K. and Kaplan, J.R. Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness. Arterioscler. Thromb. Vase. Biol. 1995; 15: 562–570.

    Article  CAS  Google Scholar 

  • Akishita, M., Ouchi, Y., Miyoshi, H., Kozaki, K., Inoue, S., Ishikawa, M, Eto, M., Toba, K. and Orimo, H. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells. Atherosclerosis 1997; 130: 1–10.

    Article  PubMed  CAS  Google Scholar 

  • Alexandersen, P., Haarbo, J. and Christiansen, C. The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 1996; 125: 1–13.

    Article  PubMed  CAS  Google Scholar 

  • Alexandersen, P., Haarbo, J., Byrjalsen, I., Lawaetz, H. and Christiansen, C. Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circ Res 1999; 84: 813–819.

    Article  PubMed  CAS  Google Scholar 

  • Amowitz, L.L. and Sobel, B.E. Cardiovascular consequences of polycystic ovary syndrome. Endocrinol Metab Clin North Am 1999; 28(2): 439–458.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R.A., Ludlam, C.A. and Wu, F.C.W. Haemostatic effects of supraphysiological levels of testosterone in normal men. Thromb. Haemost. 1995b; 74: 693–697.

    PubMed  CAS  Google Scholar 

  • Angelin, B. Therapy for lowering lipoprotein(a) levels. Curr. Opin. Lipidol. 1997; 8: 337–341.

    Article  PubMed  CAS  Google Scholar 

  • Arlt, W., Haas, J., Callies, F., Reincke, M., Hubler, D., Oettel, M., Ernst, M., Schulte, H.M. and Allolio, B. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N. Eng. J. Med. 1999; 341: 1013–1020.

    Article  CAS  Google Scholar 

  • Bagatell, C.J. and Bremner, W.J. Androgen and progestagen effects on plasma lipids. Prog. Cardiovasc. Dis. 1995; 38: 255–271.

    Article  PubMed  CAS  Google Scholar 

  • Barrett-Connor, E.L. and Goodman-Gruen, D. Prospective study of endogenous sex hormones and fatal cardiovascular disease in postmenopausal women. Br. Med. J. 1995; 311: 1193–1196.

    Article  CAS  Google Scholar 

  • Barrett-Connor, E. and Goodman-Gruen, D. The epidemiology of DHEAS and cardiovascular disease. Ann. N. Y. Acad. Sci. 1995; Dec 774: 259–270.

    Article  PubMed  CAS  Google Scholar 

  • Behre HM, Simoni M, Nieschlag E Strong association between serum levels of leptin and testosterone in men. Clin. Endocrinol. 1997; 47: 237–240.

    Article  CAS  Google Scholar 

  • Benten, W.P., Lieberherr, M., Giese, G., Wrehlke, C, Guo, Z. and Wunderlich, F. Functional testosterone receptors in plasma membranes of T cells. FASEB J. 1999; 13: 123–133.

    PubMed  CAS  Google Scholar 

  • Bernini. G.P., Sgro, M., Moretti, A., Argenio, G.F., Barlascini, CO., Cristofani, R. and Salvetti, A. Endogenous androgens and carotid intimal-medial thickness in women. J. Clin. Endocrinol. Metab. 1999; 84: 2008–2012.

    Article  PubMed  CAS  Google Scholar 

  • Birdsall, M., Farquhar, C. and White, H. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Ann. Intern. Med. 1997; 126: 32–35.

    PubMed  CAS  Google Scholar 

  • Björntorp, P. The regulation of adipose tissue distribution in humans Int. J. Obesity 1996; 20: 291–302

    Google Scholar 

  • Bruck, B., Brehme, U., Gugel, N., Hanke, S., Finking, G., Lutz, C, Benda, N., Schmahl, F. W., Haasis, R. and Hanke, H. Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits. Arterioscler. Thromb. Vase. Biol. 1997; 17: 2192–2199.

    Article  CAS  Google Scholar 

  • Carani, C, Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K.S. and Simpson, E.R. Effect of testosterone and oestradiol in a man with aromatase deficiency. New Eng. J. Med. 1997; 337: 91–95.

    Article  PubMed  CAS  Google Scholar 

  • Ceballos, G., Figueroa, L., Rubio, I., Gallo, G., Garcia, A., Martinez, A., Yanez, R., Perez, J., Morato, T. and Chamorro, G. Acute and nongenomic effects of testosterone on isolated and perfused rat heart. J. Cardiovasc. Pharmacol. 1999; 33: 691–697.

    Article  PubMed  CAS  Google Scholar 

  • Chou, T.M., Sudhir, K., Hutchison, S.J., Ko, E., Amidon, T.M., Collins, P. and Chatterjee, K. Testosterone induces dilatation of canine coronary conductance and resistance arteries in vivo. Circulation 1996; 94: 2614–2619.

    Article  PubMed  CAS  Google Scholar 

  • Costarella, C.E., Stallone, J.N., Rutecki, G.W. and Whittier, F.C. Testosterone causes direct relaxation of rat thoracic aorta. J. Pharmacol. Experiment Therap. 1996; 277: 34–39.

    CAS  Google Scholar 

  • Couillard, C, Gagnon, J., Bergnon, J., et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroids hormone concentration in men: the HERITAGE family study. J. Clin. Endocrinol. Metab. 2000; 85: 1026–1031.

    Article  PubMed  CAS  Google Scholar 

  • D’Agostino, P., Milano, S., Barbera, C, Di Bella, G., La Rosa, M., Ferlazzo, V., Farruggio, R., Miceli, D.M., Miele, M., Castagnetta, L. and Cillari, E. Sex hormones modulate inflammatory mediators produced by macrophages. Ann. N. Y. Acad. Sci. 1999; 876: 426–429.

    Article  PubMed  Google Scholar 

  • Dahlgren, E., Landin, K., Krotkiewski, M., Holm, G., Janson, P.O. Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod. 1998; 13: 2706–2711.

    Article  PubMed  CAS  Google Scholar 

  • Davis, S.R. and Tran, J. Testosterone influences libido and well being in women. Trends in Endocrinology & Metabolism 2001; 12: 33–37.

    Article  CAS  Google Scholar 

  • De Pergola, G. The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. Int. J. Obes. Relat. Metab. Disord. 2000; 24 Suppl. 2: S59–63.

    Article  Google Scholar 

  • Diamanti-Kandarakis, E., Mitrakou, A., Raptis, S., Tolis, G. and Duleba, A.J. The effect of a pure antiandrogen receptor blocker, flutamide, on the lipid profile in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 1998; 83: 2699–2705.

    Article  PubMed  CAS  Google Scholar 

  • Diamond, M.P., Grainger, D., Diamond, M.C., Sherwin, R.S. and Defronzo, R.A. Effects of methyltestosterone on insulin secretion and sensitivity in women. J. Clin. Endocrinol. Metab. 1998; Dec; 83(12): 4420–4425.

    Article  PubMed  CAS  Google Scholar 

  • Diano, S., Horvath, T.L., Mor, G., Register, T., Adams, M., Harada, N. and Naftolin, F. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause 1999; Spring;6(l): 21–28.

    PubMed  CAS  Google Scholar 

  • Dunaif, A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 1997; 18: 774–800.

    Article  PubMed  CAS  Google Scholar 

  • Dunaif, A. and Thomas, A. Current concepts in the polycystic ovarian syndrome. Ann. Rev. Med. 2001; 52: 401–419.

    Article  PubMed  CAS  Google Scholar 

  • Elbers, J.M., de Jong, S., Teerlink, T., Asscheman, H., Seidell, J.C. and Gooren, L.J. Changes in fat cell size and in vitro lipolytic activity of abdominal and gluteal adipocytes after a one-year cross-sex hormone administration in transsexuals. Metabolism 1999; Nov;48(11): 1371–1377.

    Article  PubMed  CAS  Google Scholar 

  • Elhage, R., Arnal, J.F., Pieraggi, M-T., Duverger, N., Fievet, C, Faye, J.C. and Bayard, F. 17β-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vase. Biol. 1997; 17: 2679–2684.

    Article  CAS  Google Scholar 

  • Eri, L.M., Urdal, P. and Bechensteen, A.G. Effects of the luteinizing hormone-releasing hormone agonist leuprolide on lipoproteins, fibrinogen and plasminogen activator inhibitor in patients with benign prostatic hyperplasia. J. Urol. 1995b; 154: 100–104.

    Article  PubMed  CAS  Google Scholar 

  • Farhat, M.Y., Wolfe, R., Vargas, R., Foegh, M.L. and Ramwell, E. Effect of testosterone treatment on vasoconstrictor response of left anterior descend coronary artery in male and female pigs. J. Cardiovasc. Pharmacol. 1995; 25: 495–500.

    Article  PubMed  CAS  Google Scholar 

  • Feldman, H.A., Johannes, C.B., McKinlay, J.B. and Longcope, C. Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol 1998; 8: 217–228.

    Article  PubMed  CAS  Google Scholar 

  • Fogelberg, M., Björkhem, I., Diczfalusy, U. and Henriksson, P. Stanozolol and experimental atherosclerosis: atherosclerosis development and blood lipids during anabolic steroid therapy of New Zealand white rabbits. Scand. J. Clin. Lab. Invest. 1990; 50: 693–700.

    Article  PubMed  CAS  Google Scholar 

  • Furutama, D., Fukui, R., Amakawa, M. and Ohsawa, N. Inhibition of migration and proliferation of vascular smooth muscle cells by dehydroepiandrosterone sulfate. Biochim. Biophys. Acta. 1998; 27;1406(1): 107–114.

    Article  PubMed  CAS  Google Scholar 

  • Fuster, V. Mechanisms lead to myocardial infarction: insights from studies in vascular biology. Circulation 1994; 90: 2126–2146.

    Article  PubMed  CAS  Google Scholar 

  • Geary, G.G., Krause, D.N. and Duckies, S.P. Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms. Am. J. Physiol. Heart Circ. Physiol. 2000;279:610–618.

    Google Scholar 

  • Grumbach, M.M. and Auchus, R.J. Estrogen: consequences and implications of human mutations in synthesis and action. J. Clin. Endocrinol. Metab. 1999; 84: 4677–4694.

    Article  PubMed  CAS  Google Scholar 

  • Guzick, D.S., Talbott, E.O, Sutton-Tyrrell, K., Herzog, H.C., Kuller, L.H. and Wolfson, S.K. Jr. 1996; Carotid atherosclerosis in women with polycystic ovary syndrome: initial results from a case-control study. Am. J. Obstet. Gynecol. 174: 1224–1229; discussion 1229–1232.

    Article  PubMed  CAS  Google Scholar 

  • Harada, Sasano, Murakami, H., Ohkuma, T., Nagura, H. and Takagi, Y. Localised expression of aromtase in human vascular tissue. Circ, Res, 1999; 84: 1285–1291.

    Article  CAS  Google Scholar 

  • Hautanen, A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int. J. Obes. Relat. Metab. Disord. 2000; 24 Suppl 2: 64–70.

    Article  Google Scholar 

  • Hayashi, T., Esaki, T., Muto, E., Kano, H., Asai, Y., Thakur, N.K., Sumi, D., Jayachandran, M. and Iguchi, A. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Arterioscler. Thromb. Vase. Biol. 2000; 20: 782–792.

    Article  CAS  Google Scholar 

  • Heine, P.A., Taylor, J.A., Iwamoto, G.A., Lubahn, D.B. and Cooke, P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 2000; 97: 12729–12734.

    Article  PubMed  CAS  Google Scholar 

  • Hergenc, G, Schulte, H, Assmann, G, and von Eckardstein, A. Associations of obesity markers, insulin, and sex hormones with HDL-cholesterol levels in Turkish and German individuals. Atherosclerosis 1999; 145, 147–156.

    Article  PubMed  CAS  Google Scholar 

  • Herman, S.M., Robinson, J.T.C., McCredie, R.J., Adams, M.R., Boyer, M.J. and Celermajer, D.S. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler. Thromb. Vase. Biol. 1997; 17: 2004–2009.

    Article  CAS  Google Scholar 

  • Herrington, D.M., Reboussin, D.M., Brosnihan, K.B., Sharp, P.C., Shumaker, S.A., Snyder, T.E., Furberg, CD., Howalchuk, G.J., Stuckey, T.D., Rogers, W.J., Givens, D.H. and Waters, D. Effects of estrogen replacement on the progression of coronary artery artherosclerosis. N. Eng. J. Med. 2000; 343: 522–529.

    Article  CAS  Google Scholar 

  • Hishikawa, K., Nakaki, T., Marumo, T., Suzuki, H., Kato, R. and Saruta, T. Up regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett 1995; 360: 291–295.

    Article  PubMed  CAS  Google Scholar 

  • Hodges, Y.K., Tung, L., Yan, X.D., Graham, J.D., Horwitz, K.B., Horwitz, L.D. Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation 2000; 101: 1792–1798.

    Article  PubMed  CAS  Google Scholar 

  • Hulley, S., Grady, D., Bush, T., Furberg, C, Herrington, D.M., Riggs, B. and Vittinghoff, E. Randomised trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women: The HERS study. JAMA 1998; 280: 605–613.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, P.J., Gurnell, E.M., Huppert, F.A., Richards, C, Prevost, A.T., Wass, J.A.H., Herbert, J. and Chatterjee, V.K.K. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomised, double blind trial. J. Clin. Endocrinol. Metab. 2000; 85: 4650–4656.

    Article  PubMed  CAS  Google Scholar 

  • Hutchison, S.J., Sudhir, K., Chou, T.M., Sievers, R.E., Zu, B.Q., Sun, Y.P., Deedwania, P.C., Gintz, S.A., Parmely, W.W. and Chatterjee, K. Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. J. Am. Coll. Cardiol. 1997b; 29: 800–807.

    Article  PubMed  CAS  Google Scholar 

  • Kimura, M., Tanaka, S., Yamada, Y., Kiuchi, Y., Yamakawa, T. and Sekihara, H. Dehydroapiandrosterone decreases serum tumor necrosis factor a and restores insulin sensitivity: Independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 1998; 129: 3249–3253.

    Article  Google Scholar 

  • Kolodgie, F.D., Jacob, A., Wilson, P.S., Carlson, G.C., Farb, A., Verma, A. and Virmani, R. Estradiol attenuates directed migration of vascular smooth muscle cells in vitro. Am. J. Pathol. 1996; 148: 969–976.

    PubMed  CAS  Google Scholar 

  • Kolodziejczyk, B., Duleba, A.J., Spaczynski, R.Z. and Pawelczyk, L Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil. Steril. 2000; 73: 1149–1154.

    Article  PubMed  CAS  Google Scholar 

  • Larsen, B.A., Nordestgaard, B.G., Stender, S. and Kjeldsen, K. Effect of testosterone on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levels. Atherosclerosis 1993; 99: 79–86.

    Article  PubMed  CAS  Google Scholar 

  • Leenen, R., van der Kooy, K., Seidell, J.C., Deurenberg, P. and Koppeschaar, H.P. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J. Clin. Endocrinol. Metab. 1994; 78: 1515–1520.

    Article  PubMed  CAS  Google Scholar 

  • Libby, P. Molecular bases of the acute coronary syndromes. Circulation 1995; 91: 2844–2850.

    Article  PubMed  CAS  Google Scholar 

  • Lieberherr, M. and Grosse, B. Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. J. Biol. Chem. 1994; 269: 7217–7223.

    PubMed  CAS  Google Scholar 

  • Lobo, R.A. and Carmina, E. The importance of diagnosing the polycystic ovary syndrome. Ann. Intern. Med. 2000; 132: 989–993.

    PubMed  CAS  Google Scholar 

  • Lovejoy, J.C., Bray, G.A., Bourgeois, M.O., Macchiavelli, R., Rood, J.C., Greeson, C. and Partington, C. Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women — a clinical research center study. J. Clin. Endocrinol. Metab. 1996; Jun;81(6): 2198–2203.

    Article  PubMed  CAS  Google Scholar 

  • Masuda, A., Mathur, A. and Halushka, P.V. Testosterone increases thromboxane A2 receptors in cultured rat smooth muscle cells. Circ. Res. 1995; 69: 638–643.

    Article  Google Scholar 

  • McCredie, R.J., McCrohon, J.A., Turner, L., Griffiths, K.A., Handelsman, D.J. and Celermajer, D.S. Vascular reactivity is impaired in genetic females taking high-dose androgens. J. Am. Coll. Cardiol. 1998; 32: 1331–1335.

    Article  PubMed  CAS  Google Scholar 

  • McCrohon, J.A., Death, A.K., Nakhla, S., Jessup, W., Handelsman, D.J., Stanley, K.K. and Celermajer, D.S. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis. Circulation 2000; Jan 25;101(3): 224–226.

    Article  PubMed  CAS  Google Scholar 

  • Morghetti, P., Tosi, F., Castello, R. et al. The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women. J. Clin. Endocrinol. Metab. 1997; 81: 952–960.

    Article  Google Scholar 

  • Morishima, A., Grumbach, M.M., Simpson, E.R., Fisher, C. and Qin, K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 1995; Dec;80(12): 3689–3698.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, J.G. and Khalil, R.A. Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J. Pharmacol. Exp. Ther. 1999;291:44–45.

    PubMed  CAS  Google Scholar 

  • Nestler, J.E., Jakubowicz, D.J., de Vargas, A.F., Brik, C, Quintero, N. and Medina, F. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J. Clin. Endocrinol. Metab. 1998; 83: 2001–2005.

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag, E., Nieschlag, S. and Behre, H.M. Lifespan and testosterone. Nature 1993; 366: 215.

    Article  PubMed  CAS  Google Scholar 

  • Nilsson, B.O., Ekblad, E., Heine, T. and Gustafsson, J. Increased magnitude of relaxation to oestrogen in aorta from oestrogen receptor beta knock-out mice. J. Endocrinol. 2000; Aug; 166(2): R5–9.

    Article  PubMed  CAS  Google Scholar 

  • Nippoldt, T.B. and Nair, K.S. 1998; Is there a case for DHEA replacement? Bailliere’s Clin Endocrinol Metab 12: 507–520

    Article  CAS  Google Scholar 

  • Pasquali, R. and M. Insulin sensitizing agents and polycystic ovary syndrome. Eur J Endocrinol. 1998; 138: 253–254.

    Article  PubMed  CAS  Google Scholar 

  • Pasquali, R., Macor, C, Vicennati, V., Novo, F., De Lasio, R., Mesini, P., Boschi, S., Casimirri, F. and Vettor, R. Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men. Metabolism. 1997; 46:526–529.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, G.B., Pinkernell, B.H. and Jing, T.Y. Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arterioscler. Thromb. Vase. Biol. 1997; Apr;17(4): 695–701.

    Article  CAS  Google Scholar 

  • Rajkhowa, M., Glass, M.R., Rutherford, A.J., Michelmore, K. and Balen, A.H. Polycystic ovary syndrome: a risk factor for cardiovascular disease? B J Obs Gynecol 2000; 107: 11–18.

    Article  CAS  Google Scholar 

  • Ridker, PM Evaluating novel cardiovascular risk factors: can we better predict heart attacks? Ann. Intern. Med. 1999; 130: 933–937.

    PubMed  CAS  Google Scholar 

  • Rosano, G.M., Leonardo, F., Pagnotta, P., Pellicia, F., Panina, G., Cerquetani, E., della Monica, P.L., Bonfigli, B., Volpe, M. and Chierchia, S.L. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation. 1999; 99: 1666–1670.

    Article  PubMed  CAS  Google Scholar 

  • Ross, R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 1999; 340: 115–126.

    Article  PubMed  CAS  Google Scholar 

  • Rubanyi, G.M., Frey, A.D., Kauser, K., Sukovich, D., Burton, G., Lubahn, D.B., Couse, J.F., Curtis, S.W. and Korach, K.S. Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. J. Clin. Invest. 1997; 99: 2429–2437.

    Article  PubMed  CAS  Google Scholar 

  • Sacks, F.M. and Walsh, B.W. Sex hormones and lipoprotein metabolism. Curr. Opin. Lipidol. 1994;5:236–240.

    Article  PubMed  CAS  Google Scholar 

  • Schuler-Lüttmann, S., Mönnig, G., Enbergs, A., Schulte, H., Breithardt, G., Assmann, G., Kerber, S. and von Eckardstein, A. Insulin-like growth factor binding protein-3 is associated with the presence and extent of coronary arteriosclerosis. Arterioscler. Thromb. Vase. Biol. 2000; 20: el0–el5.

    Article  Google Scholar 

  • Shlipak, M.G., Simon, J.A., Vittinghoff, E., Lin, F., Barrett-Connor, E., Knopp, R.H., Levy, R.I. and Hulley, S.B. Estrogen and progestin, lipoprotein(a), and the risk of recurrent coronary heart disease events after menopause. JAMA 2000; 283: 1845–1852.

    Article  PubMed  CAS  Google Scholar 

  • Smith, E.P., Boyd, J., Frank, G.R., Takahashi, H., Cohen, R.M., Specker, B., Williams, T.C., Lubahn, D.B. and Korach, K.S. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med. 1994; 331: 1056–1061.

    Article  PubMed  CAS  Google Scholar 

  • St. Clair, R.W. Effects of estrogens on macrophage foam cells: a potential target for the protective effects of estrogens on atherosclerosis. Curr. Opin. Lipidol. 1997; 8: 281–286.

    Article  PubMed  CAS  Google Scholar 

  • Straub, R.H., Konecna, L., Hrach, S., Rothe, G., Kreutz, M., Scholmerich, J., Falk, W. and Lang, B. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum Interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in-vitro: Possible link between endocrinosenescence and immunosenescence. J. Clin. Endocrinol. & Metabolism 1998; 83: 2012–2017.

    Article  CAS  Google Scholar 

  • Sudhir, K., Chou, T.M., Chatterjee, K., Smith, E.P., Williams, T.C., Kane, J.P., Malloy, M.J., Korach, K.S. and Rubanyi, G.M. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation 1997a; 96: 3774–3777.

    Article  PubMed  CAS  Google Scholar 

  • Sudhir, K., Chou, T.M., Messina, L.M., Hutchison, S.J., Korach, K.S., Chatterjee, K. and Rubanyi, G.M. Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet 1997b; 349: 1146–1147.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, M.L., Martinez, CM., Gennis, P. and Gallagher E.J. The cardiac toxicity of anabolic steroids. Prog. Cardiovas. Dis. 1998; 41: 1–15.

    Article  CAS  Google Scholar 

  • Talbott, E.O., Guzick, D.S., Sutton-Tyrrell, K., McHugh-Pemu, K.P., Zborowski, J.V., Remsberg, K.E. and Kuller, L.H. Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arterioscler. Thromb. Vase. Biol. 2000; 20: 2414–2421.

    Article  CAS  Google Scholar 

  • Tan, K.C., Shiu, S.W. and Kung, A.W. Alterations in hepatic lipase and lipoprotein subfractions with transdermal testosterone replacement therapy. Clin. Endocrinol. (Oxf) 1999;51:765–769.

    Article  CAS  Google Scholar 

  • Taniguchi, S., Yanase, T., Kobayashi, K., Takayanagi. R, and Nawata, H. Dehydroepiandrosterone markedly inhibits the accumulation of cholesteryl ester in mouse macrophage J774-1 cells. Atherosclerosis 1996; 27;126(1): 143–154.

    Article  PubMed  CAS  Google Scholar 

  • Tchernof, A., Labrie, F., Belanger, A. and Despres, J.P. Obesity and metabolic complications: contribution of dehydroepiandrosterone and other steroid hormones. J. Endocrino. 1996; 150 Suppl:S: 155–164.

    Google Scholar 

  • Teoh, H., Quan, A., Leung, S.W. and Man, R.Y. Differential effects of 17beta-estradiol and testosterone on the contractile responses of porcine coronary arteries. Br. J. Pharmacol. 2000; 129:1301–1308.

    Article  PubMed  CAS  Google Scholar 

  • Toda, T., Toda, Y., Cho, B.H. and Kummerow, F.A. Ultrastructural changes in the comb and aorta of chicks fed excess testosterone. Atherosclerosis 1984; 51: 47–53.

    Article  PubMed  CAS  Google Scholar 

  • Tomita, T., Sawamura, F., Uetsuka, R., Chiba, T., Miura, S., Ikeda, M. and Tomita, I. Inhibiion of cholesteryl ester accumulation by 17β-estradiol in macrophges through activation of neutral cholesterol esterase. Biochim Biophys Acta 1996; 1300: 210–218.

    Article  PubMed  Google Scholar 

  • Tsai, E.C., Boyko, E.J., Leonetti, D.L. and Fujimoto, W.Y. Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. Int. J. Obes. Relat. Metab. Disord. 2000;24:485–491.

    Article  PubMed  CAS  Google Scholar 

  • van Kesteren, P.J., Asscheman, H., Megens, J.A. and Gooren, L.J. Mortality and morbidity in transsexual subjects treated with cross-sex hormones. Clin. Endocrinol. 1997; 47: 337–342.

    Article  Google Scholar 

  • von Dehn, G., von Dehn, O., Volker, W., Langer, C, Weinbauer, G.F., Behre, H.M., Nieschlag, E., Assmann, G. and von Eckardstein, A. Atherosclerosis in apolipoprotein E-deficient mice is increased by exogenous androgens and decreased by suppression of endogenous testosterone. 2001; Horm. Metab. Res. in press.

    Google Scholar 

  • von Eckardstein, A. and Assmann, G. Prevention of coronary heart disease by raising of HDL cholesterol? Curr. Opin. Lipidol, 2000; 11: 627–637.

    Article  Google Scholar 

  • Wang, C., Swedloff, R.S., Iranmanesh, A., Dobs, A., Snyder, P.J., Cunningham, G., Matsumoto, A.M., Weber, T. and Berman, N. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group. J. Clin. Endocrinol. Metab. 2000; 85: 2839–2853.

    Article  PubMed  CAS  Google Scholar 

  • Webb, CM., Adamson, D.L., de Zeigler, D. and Collins, P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am. J. Cardiol. 1999; 83: 437–439.

    Article  PubMed  CAS  Google Scholar 

  • Wild, R.A. Metabolic aspects of polycystic ovary syndrome. Semin, Reprod, Endocrinol, 1997; 15(2): 105–110.

    Article  CAS  Google Scholar 

  • Wild, S., Pierpoint, T., McKeigue, P. and Jacobs, H.S. Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study.. Clin. Endocrinol. (Oxf) 2000; 52: 595–600.

    Article  CAS  Google Scholar 

  • Wilson, J.D. and Roehrborn, C. Long-term consequence of castration in men: lessons from the skoptzy and the eunuchs of the Chinese and Ottoman courts. J. Clin. Endocrinol. Metab. 1999;84:4324–4331.

    Article  PubMed  CAS  Google Scholar 

  • Winkler, U.H. Effects of androgens on haemostasis. Maturitas 1996; 24: 147–155.

    PubMed  CAS  Google Scholar 

  • Yoshida, Y., Nakamura, Y., Sugino, N., Shimamura, K., Ono, M. and Kato, H. Changes in interleukin 1 production of peritoneal macrophages during estrous cycle in golden hamsters. Endocrine J. 1996; 43: 151–156.

    Article  CAS  Google Scholar 

  • Yue, P., Chatterjee, K., Beale, C, Poole-Wilson, P.A. and Collins, P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995; 91: 1154–1160.

    Article  PubMed  CAS  Google Scholar 

  • Zhu, X.D., Bonet, B. and Knopp, R.H. 17β-estradiol, progesterone, and testosterone inversely modulate low density lipoprotein oxidation and cytotoxicity in cultured placental trophoblast and macrophages. Am. J. Obstet. Gynecol. 1997; 177: 196–209.

    Article  PubMed  CAS  Google Scholar 

  • Zitzmann, M. and Nieschlag, E. Testosterone levels in healthy men and their relation to behavioural and physical characteristics: facts and constructs. Eur. J. Endocrinol. 2001; (in press).

    Google Scholar 

  • Zitzmann, M., Brune, M., Kornmann, B., Gromoll, J., von Eckardstein, S., von Eckardstein, A. and Nieschlag, E. The CAG repeat polymorphism in the androgen receptor gene affects high density lipoprotein cholesterol and arterial vasoreactivity. 2001; Submitted for publication.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Clinical Chemistry, University Hospital of Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland

    Arnold von Eckardstein

  2. Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Oxford Road, Manchester, MI3 9WL, UK

    Fredrick C. W. Wu

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  1. Arnold von Eckardstein
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  1. University of Rochester Medical Center, UK

    Chawnshang Chang

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von Eckardstein, A., Wu, F.C.W. (2002). Androgens and Coronary Artery Disease. In: Chang, C. (eds) Androgens and Androgen Receptor. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1161-8_17

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  • DOI: https://doi.org/10.1007/978-1-4615-1161-8_17

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