Abstract
The HIV Sequence Database has been in existence now for 15 years, and its companion HIV Immunology Database for 6 years. The sequence database serves the HIV research community by bringing together the data accrued through the global sequencing effort into an accessible format, so that new studies can readily build on previous work. The database has also provided a center for HIV researchers to develop a useful nomenclature system, which has enabled more consistent and effective communication. The immunology database is integrated with the sequence database so that T-cell and B-cell antigenic regions can be studied from perspective sequence variability, the relative location of epitopes in proteins mapped, and studies cross-compared. Summaries of what is known about an epitope or antibody and literature links are available. Basic sequence analysis and immunological computational tools, designed specifically to aid HIV researchers but often with more general applications, have been developed at the database and are widely used. This kind of integrated database system can be useful for highly variable pathogens where extensive immunological characterization is underway. Rapid advances in sequencing and immunological method technologies will make combined database/computational facilitates an increasingly important aspect of pathogen-host studies.
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Korber, B., Kuiken, C. (2002). The HIV Databases: History, Design and Function. In: Leitner, T. (eds) The Molecular Epidemiology of Human Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1157-1_4
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DOI: https://doi.org/10.1007/978-1-4615-1157-1_4
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