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Genomic Diversity of Human Papillomaviruses and its Impact on Molecular Epidemiological Research

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The Molecular Epidemiology of Human Viruses

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Abstract

Papillomas are benign epithelial neoplastic lesions, many of which are referred to as “warts” in vernacular language. Experiments that implied a viral agent as cause of papillomas date back about 100 years. For a long time, they addressed certain animal systems like the lesions in cotton tail rabbits and the common warts of humans, and the agents causing these lesions became termed “papillomaviruses” (PVs). In those times, PVs attracted little scientific attention, since these neoplasias cause only moderate public health or veterinary problems. This changed in the early 1980s, when numerous human papillomaviruses (HPVs) were found to be associated with and to cause cervical cancer and various other benign and malignant neoplastic lesions (zur Hausen, 1996). The objective of this chapter is to give a general introduction to PV biology and to discuss in some detail the state of the art of our knowledge of PV evolution and its impact on molecular epidemiology and etiology of HPV infections and HPV caused lesions.

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  1. Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore, 117609

    Hans-Ulrich Bernard

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  1. Swedish Institute for Infectious Disease Control, 17182, Solna, Sweden

    Thomas Leitner

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Bernard, HU. (2002). Genomic Diversity of Human Papillomaviruses and its Impact on Molecular Epidemiological Research. In: Leitner, T. (eds) The Molecular Epidemiology of Human Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1157-1_18

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