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Ionic Channels and Fibrillation

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Heart Cell Coupling and Impulse Propagation in Health and Disease

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 12))

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Abstract

Cardiac fibrillation is a major health problem in industrialized society today. In the United States alone, ventricular fibrillation (VF) is responsible for approximately 300,000 sudden cardiac deaths (Myerburg,Catellanos,1997). On the other hand, atrial fibrillation (AF) afflicts over 2 million Americans, (Feinberg et a1,1995) which makes it the most prevalent cardiac arrhythmia in clinical practice. While AF in and of itself does not usually lead to death, it is the most important cause of stroke. (Wolf et a1,1991). Because of the alarming nature of these statistics, understanding the mechanisms underlying fibrillation of the heart is very critical.

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  1. Dept. of Pharmacology, SUNY Upstate Medical University, Syracuse, NY

    Justus M. B. Anumonwo, Omer Berenfeld, Amit Dhamoon & José Jalife

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  1. Justus M. B. Anumonwo
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Anumonwo, J.M.B., Berenfeld, O., Dhamoon, A., Jalife, J. (2002). Ionic Channels and Fibrillation. In: Heart Cell Coupling and Impulse Propagation in Health and Disease. Basic Science for the Cardiologist, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1155-7_13

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