ATP Synthesis from Carbon-based Fuels by Glycolysis and Glycogenolysis
The metabolic machinery needed to meet the energy demands of the myocyte without allowing [ATP] to fall is impressive. ATP production by oxidative phosphorylation in the mitochondria is usually sufficient to meet the constantly changing demands for energy (0.1–1 mM/s) in the heart. ATP production by glycolysis makes a quantitatively trivial contribution (0.03 mM/s) to overall ATP production by the normal myocyte. The amount of ATP produced from glucose by glycolysis is a small fraction of the amount made as a result of the oxidation of glucose. Nonetheless, because glucose and glycogen can be metabolized rapidly, they are important sources of ATP during rapid transitions to increased work or in ATP supply/demand mismatches, which occur in ischemia.
KeywordsGlycolytic Pathway Glycogen Synthesis Glycogen Phosphorylase Hypertrophied Heart Glycolytic Rate
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- 4.Abel ED, Kaulbach HC, Tian R, Hopkins JCA, Duffy J, Doetschman T, Minnemann T, Boers M-E, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after deletion of GUT4 from the heart.J Clin Invest.1999;104:1703–1714.PubMedCrossRefGoogle Scholar
- 7.Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.Am JPhysiol. 1994:2 Pt 2.Google Scholar
- 9.Russell RRr, Cline GW, Guthrie PH, Goodwin GW, Shulman GI, Taegtmeyer H. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation.J Clin Invest.1997;100:2892–2899.PubMedCrossRefGoogle Scholar
- 10.Goodwin GW, Ahmad F, Doenst T, Taegtmeyer H. Energy provision from glycogen, glucose, and fatty acids on adrenergic stimulation of isolated working rat hearts.Am JPhysiol.1998;274:H1239–1247.Google Scholar
- 12.Lewandowski ED, Ingwall JS. The physiological chemistry energy production in the heart. In: Schlant RC, Alexander RW, eds.The heart: Arteries and veins.8 ed. New York: McGraw Hill; 1994:153–164.Google Scholar