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Degradation and Synthesis of ATP

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ATP and the Heart

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 11))

Abstract

ATP is degraded (Figure 5.1) by sequentially hydrolyzing the three phosphoryl groups to form adenosine. Adenosine is then deaminated to form inosine. Finally the glycosidic bond joining the ribose and the purine ring is cleaved, forming hypoxanthine. These degradative reactions occur in both myocytes and non-myocytes; however, the activities of the enzymes converting adenosine to inosine, inosine to hypoxanthine and hypoxanthine to xanthine (not shown) are so much higher in non-myocytes that most of their metabolism occurs in these cells and in the extracellular space, not the myocyte. There is another pathway leading to adenosine production, the S-adenosylhomocysteine pathway (where methionine is converted to homocysteine); however, most of the adenosine in the normal heart is made from AMP.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Joanne S. Ingwall Ph.D. (Senior Biochemist, Director, NMR Laboratory for Physiological Chemistry, Professor of Medicine (Physiology)

  2. Harvard Medical School, Boston, USA, MA

    Joanne S. Ingwall Ph.D. (Senior Biochemist, Director, NMR Laboratory for Physiological Chemistry, Professor of Medicine (Physiology)

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  1. Joanne S. Ingwall Ph.D.
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© 2002 Springer Science+Business Media New York

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Ingwall, J.S. (2002). Degradation and Synthesis of ATP. In: ATP and the Heart. Basic Science for the Cardiologist, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1093-2_5

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  • DOI: https://doi.org/10.1007/978-1-4615-1093-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5391-1

  • Online ISBN: 978-1-4615-1093-2

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