ATP and the Heart: An Overview
Part of the Basic Science for the Cardiologist book series (BASC, volume 11)
Figure 1.1 is a cartoon summarizing the story of ATP and the Heart. On the right are the primary ATP utilizing reactions: myosin ATPase in the myofibril, the Ca2+-ATPase in the sarcoplasmic reticulum and the Nat, K+-ATPase in the sarcolemma. These ATPase reactions hydrolyze ATP:
where ADP is adenosine diphosphate and Pi is inorganic phosphate. Also shown is a growing polypeptide chain representing the requirement of GTP for protein (and nucleic acid) synthesis. On the left, the primary ATP synthesizing pathways are shown: oxidative phosphorylation in the mitochondria and the glycolytic pathway.
$$ ATP \to ADP + Pi $$
KeywordsHydrolysis Ischemia Adenosine Polypeptide Adenine
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© Springer Science+Business Media New York 2002