ATP and the Heart: An Overview

  • Joanne S. Ingwall
Part of the Basic Science for the Cardiologist book series (BASC, volume 11)


Figure 1.1 is a cartoon summarizing the story of ATP and the Heart. On the right are the primary ATP utilizing reactions: myosin ATPase in the myofibril, the Ca2+-ATPase in the sarcoplasmic reticulum and the Nat, K+-ATPase in the sarcolemma. These ATPase reactions hydrolyze ATP:
$$ ATP \to ADP + Pi $$
where ADP is adenosine diphosphate and Pi is inorganic phosphate. Also shown is a growing polypeptide chain representing the requirement of GTP for protein (and nucleic acid) synthesis. On the left, the primary ATP synthesizing pathways are shown: oxidative phosphorylation in the mitochondria and the glycolytic pathway.


Adenylate Kinase Adenosine Diphosphate Myosin ATPase ATPase Reaction Creatine Kinase Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Joanne S. Ingwall
    • 1
    • 2
  1. 1.Division of Cardiovascular Medicine Department of MedicineBrigham and Women’s HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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