ATP and the Heart: An Overview

  • Joanne S. Ingwall
Part of the Basic Science for the Cardiologist book series (BASC, volume 11)

Abstract

Figure 1.1 is a cartoon summarizing the story of ATP and the Heart. On the right are the primary ATP utilizing reactions: myosin ATPase in the myofibril, the Ca2+-ATPase in the sarcoplasmic reticulum and the Nat, K+-ATPase in the sarcolemma. These ATPase reactions hydrolyze ATP:
$$ ATP \to ADP + Pi $$
where ADP is adenosine diphosphate and Pi is inorganic phosphate. Also shown is a growing polypeptide chain representing the requirement of GTP for protein (and nucleic acid) synthesis. On the left, the primary ATP synthesizing pathways are shown: oxidative phosphorylation in the mitochondria and the glycolytic pathway.

Keywords

Hydrolysis Ischemia Adenosine Polypeptide Adenine 

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Joanne S. Ingwall
    • 1
    • 2
  1. 1.Division of Cardiovascular Medicine Department of MedicineBrigham and Women’s HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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