Arsenic carcinogenicity: Relevance of c-Src activation

  • Petia P. Simeonova
  • Michael I. Luster
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 37)


Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation. (Mol Cell Biochem 234/235: 277 282, 2002)

Key words

gene expression reactive oxygen species skin cancer bladder cancer 


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Petia P. Simeonova
    • 1
  • Michael I. Luster
    • 1
  1. 1.Toxicology and Molecular Biology BranchHealth Effects Laboratory DivisionMorgantownUSA

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