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Cytokine polymorphisms in silicosis and other pneumoconiosis

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Oxygen/Nitrogen Radicals: Cell Injury and Disease

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 37))

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Abstract

Silicosis and coal workers’ pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-a (TNF-a) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition from simple to progressive massive fibrosis. In this review we discuss genetic polymorphisms responsible for regulating the production of these proinflammatory cytokines and their role in modifying silicosis severity. (Mol Cell Biochem 234/235: 219–224, 2002)

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Author information

Authors and Affiliations

  1. Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey

    Berran Yucesoy

  2. Pathology and Physiology Research Branch, Morgantown

    Val vallyathan

  3. Biostatistics Branch, Morgantown

    Douglas P. Landsittel

  4. Toxicology and Molecular Biology Branch, Health Effects and Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA

    Petia Simeonova & Michael I. Luster

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  1. Berran Yucesoy
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  2. Val vallyathan
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  3. Douglas P. Landsittel
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  4. Petia Simeonova
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  5. Michael I. Luster
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Editors and Affiliations

  1. Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road Mall Stop B167, Morgantown, WV, 26505, USA

    Val Vallyathan , Xianglin Shi Ph.D.  & Vince Castranova ,  & 

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Yucesoy, B., vallyathan, V., Landsittel, D.P., Simeonova, P., Luster, M.I. (2002). Cytokine polymorphisms in silicosis and other pneumoconiosis. In: Vallyathan, V., Shi, X., Castranova, V. (eds) Oxygen/Nitrogen Radicals: Cell Injury and Disease. Developments in Molecular and Cellular Biochemistry, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1087-1_25

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  • DOI: https://doi.org/10.1007/978-1-4615-1087-1_25

  • Publisher Name: Springer, Boston, MA

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