Novel Compounds Acting Through Receptors and Enzyme Mediators

  • Trevor M. Penning
Part of the Medical Science Symposia Series book series (MSSS, volume 17)


This article will introduce novel steroids that have an optimal profile for the prevention of postmenopausal osteoporosis. These agents have a duality of function: they can activate the estrogen receptor (ER) but they also regulate the amount of ligand available for the ER via enzyme inhibition in a tissue-specific manner. These agents have the same clinical profile as selective estrogen receptor modulators (SERMS) but a different mode of action. This article will develop these mechanistic concepts.


Estrogen Receptor Invasive Lobular Carcinoma Selective Estrogen Receptor Modulator Hydroxysteroid Dehydrogenase Hormone Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2002

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  • Trevor M. Penning

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