Skip to main content
SpringerLink
Log in

Non-Candida Fungal Infections in the Intensive Care Unit

European Perspective

  • Chapter
Fungal Infection in the Intensive Care Unit

Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 6))

  • 89 Accesses

Abstract

Infections caused byCandidaspecies are the commonest mycological causes of infection in the intensive care unit (ICU). However non-Candida fungal infections are increasingly seen as either a presenting cause for ICU admission or following nosocomial acquisition in a critically-ill patient. Most are relatively episodic.Pneumocystis cariniipneumonia (PCP) is often associated with AIDS, and aspergillosis is usually confined to immunocompromised patients although outbreaks can occur within the ICU. Cryptococcosis is an infrequent infection in Western Europe and other endemic fungal infections, such as histoplasmosis and coccidioidomycosis, occur rarely following overseas travel.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stringer JR. Pneumocystis carinii: what is it, exactly? Clin Microbiol Rev 1996;9:489–98.

    PubMed  CAS  Google Scholar 

  2. Miller R. HIV-associated respiratory diseases. Lancet 1996;348:307–12.

    Article  PubMed  CAS  Google Scholar 

  3. Torres A, El-Ebiary M, Marrades Ret al.Aetiology and prognostic factors of patients with AIDS presenting life-threatening acute respiratory failure. Eur Resp J 1995;8:1922–8.

    Article  CAS  Google Scholar 

  4. Gill JK, Greene L, Miller Ret al.ICU admission in patients infected with the human immunodeficiency virus: a multicentre survey. Anaesthesia 1999;54:727–32.

    Article  PubMed  CAS  Google Scholar 

  5. Rosen MJ, Clayton K, Schneider RFet al.Intensive care of patients with HIV infection Utilization, critical illnesses and outcomes. Am J Respir Crit Care Med 1997;155:67–71.

    PubMed  CAS  Google Scholar 

  6. Bédos JP, Dumoulin JL, Gachot Bet al. Pneumocystis cariniipneumonia requiring intensive care management: survival and prognostic study in 110 patients with human immunodeficiency virus. Crit Care Med 1999;27:1109–15.

    Article  PubMed  Google Scholar 

  7. Curtis JR, Bennett CL, Horner RDet al.Variations in intensive care unit utilization for patients with human immunodeficiency virus-relatedPneumocystis cariniipneumonia: importance of hospital characteristics and geographic location. Crit Care Med 1998;26:668–75.

    Article  PubMed  CAS  Google Scholar 

  8. Curtis JR. ICU outcomes for patients with HIV infection, a moving target. Chest 1998;113:269–70.

    Article  PubMed  CAS  Google Scholar 

  9. Kumar SD, Krieger BP. CD4 lymphocyte counts and mortality in AIDS patients requiring mechanical ventilator support due toPneumocystis cariniipneumonia. Chest 1998;113:430–3.

    Article  PubMed  CAS  Google Scholar 

  10. Forrest DM, Djurdjev O, Zala Cet al.Validation of the modified multisystem organ failure score as a predictor of mortality in patients with AIDS-relatedPneumocystis cariniipneumonia and respiratory failure. Chest 1998;114:199–206.

    Article  PubMed  CAS  Google Scholar 

  11. Shelhamer JH, Gill VJ, Quinn TCet al.The laboratory evaluation of opportunistic pulmonary infections. Ann Intern Med 1996;124:585–99.

    PubMed  CAS  Google Scholar 

  12. Caliendo AM, Hewitt PL, Allega JMet al.Performance of a PCR assay for detection ofPneumocystis cariniifrom respiratory specimens. J Clin Microbiol 1998;36:979–82.

    PubMed  CAS  Google Scholar 

  13. Fishman JA. Treatment of infection due toPneumocystis cariniiAntimicrob Agents Chemother 1998;42:1309–14.

    Google Scholar 

  14. Meshnick SR. Drug-resistantPneumocystis carinii.Lancet 1999;354:1318–9.

    Article  PubMed  CAS  Google Scholar 

  15. U.S. Public Health Service and Infections Diseases Society of America Prevention of Opportunistic Infections Working Group. 1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. Ann Intern Med 1999;131:873–903.

    Google Scholar 

  16. Kovacs JA, Masur H. Prophylaxis against opportunist infections in patients with human immunodeficiency virus infection. N Engl J Med 2000;342:1416–29.

    Article  PubMed  CAS  Google Scholar 

  17. Denning DW. Invasive aspergillosis. Clin Infect Dis 1998;26:781–805.

    Article  PubMed  CAS  Google Scholar 

  18. Manuel RJ, Kibbler CC. The epidemiology and prevention of invasive aspergillosis. J Hosp Infect 1998;39:95–109.

    Article  PubMed  CAS  Google Scholar 

  19. Fridkin SK, Jarvis WR. Epidemiology of nosocomial fungal infections. Clin Microbiol Rev 1996;9:499–511.

    PubMed  CAS  Google Scholar 

  20. Hovenden JL, Nicklason F, Barnes RA. Invasive pulmonary aspergillosis in nonimmunocompromised patients. BMJ 1991;302:583–4.

    Article  PubMed  CAS  Google Scholar 

  21. Humphreys H, Johnson EM, Warnock DWet al.An outbreak of aspergillosis in a general ITU. J Hosp Infect 1990;18:167–77.

    Article  Google Scholar 

  22. Pittet D, Huguenin T, Dharan Set al.Unusual cause of lethal pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996;154:541–4.

    PubMed  CAS  Google Scholar 

  23. Singh N, Gayowski T, Wagener MM, Marino IR. Pulmonary infiltrates in liver transplant recipients in the intensive care unit. Transplantation 1999;67:1138–44.

    Article  PubMed  CAS  Google Scholar 

  24. Denning DW, Evans EGV, Kibbler CCet al.Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. Eur J Clin Microbiol Infect Dis 1997;16:424–36.

    Article  PubMed  CAS  Google Scholar 

  25. Horvath JA, Dummer S. The use of respiratory tract cultures in the diagnosis of pulmonary aspergillosis. Am J Med 1996;100: 171–8.

    Article  PubMed  CAS  Google Scholar 

  26. Denning DW. Early diagnosis of invasive aspergillosis. Lancet 2000;355:423–4.

    PubMed  CAS  Google Scholar 

  27. Maertens J, Verhaegen J, Demuynck Het al.Autopsy-controlled prospective evaluation of serial screening for circulating galactomannan by a sandwich enzyme-linked immunosorbent assay for hematological patients at risk for invasive aspergillosis. J Clin Microbiol 1999;37:3223–8.

    PubMed  CAS  Google Scholar 

  28. Skladny H, Buchheidt D, Baust Cet al.Specific detection ofAspergillusspecies in blood and bronchoalveolar lavage samples of immunocompromised patients by two-step PCR. J Clin Microbiol 1999; 37: 3865–3871.

    PubMed  CAS  Google Scholar 

  29. Working Party of the British Society for Antimicrobial Chemotherapy. Therapy of deep fungal infection in haematological malignancy. J Antimicrob Chemother 1997;40:77988.

    Google Scholar 

  30. Wong-Beringer A, Jacobs RA, Guglielmo BJ. Lipid formulations of amphotericin B: clinical efficacy and toxicities. Clin Infect Dis 1998;27:603–18.

    Article  PubMed  CAS  Google Scholar 

  31. Walsh TJ, Finberg RW, Arndt Cet al.Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. N Engl J Med 1999;340:764–71.

    Article  PubMed  CAS  Google Scholar 

  32. Ellis M, Spence D, de Pauw Bet al.An EORTC international multicenter randomized trial (EORTC number 19923) comparing two dosages of liposomal amphotericin B for treatment of invasive aspergillosis. Clin Infect Dis 1998;27:1406–12.

    Article  PubMed  CAS  Google Scholar 

  33. Morris G, Kokki MH, Anderson K, Richardson MD. Sampling of aspergillus spores in air. J Hosp Infect 2000;44:81–92.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland

    Hilary Humphreys

Authors
  1. Hilary Humphreys
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Wales College of Medicine, Cardiff, UK

    R. A. Barnes

  2. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    D. W. Warnock

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Humphreys, H. (2002). Non-Candida Fungal Infections in the Intensive Care Unit. In: Barnes, R.A., Warnock, D.W. (eds) Fungal Infection in the Intensive Care Unit. Perspectives on Critical Care Infectious Diseases, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0977-6_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0977-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5333-1

  • Online ISBN: 978-1-4615-0977-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation