Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice
The role of gastrin as a regulator of acid secretion has been appreciated for almost a century.(13) For many years it has been clear that while gastrin may act directly on parietal cells, it also acts on enterochromaffin-like (ECL) cells to control histamine release which in turn stimulates acid secretion.(33) It is presently thought that this effect is of primary physiological importance in the control of post-prandial acid secretion. In addition, gastrin has long been considered to be a regulator of gastric mucosal proliferation, although it remains controversial as to whether or not proliferating cells in the stomach normally express the gastrin-CCKB receptor, which is the main receptor mediating the effect of COOH-terminally amidated gastrins.
KeywordsAcid Secretion Parietal Cell Vesicular Monoamine Transporter Plasma Gastrin Paracrine Mediator
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