Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice
The role of gastrin as a regulator of acid secretion has been appreciated for almost a century.(13) For many years it has been clear that while gastrin may act directly on parietal cells, it also acts on enterochromaffin-like (ECL) cells to control histamine release which in turn stimulates acid secretion.(33) It is presently thought that this effect is of primary physiological importance in the control of post-prandial acid secretion. In addition, gastrin has long been considered to be a regulator of gastric mucosal proliferation, although it remains controversial as to whether or not proliferating cells in the stomach normally express the gastrin-CCKB receptor, which is the main receptor mediating the effect of COOH-terminally amidated gastrins.
KeywordsMigration Dopamine Recombination Amidated Glycine
Unable to display preview. Download preview PDF.
- 4.Blackmore, C. G., A. Varro, R. Dimaline, L. Bishop, D. V. Gallacher, and G. J. Dockray. Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage. J Physiol 531: 605–617, 2001.PubMedCrossRefGoogle Scholar
- 6.Dempsey, P. J., J. R. Goldenring, C. J. Soroka, I. M. Modlin, R. W. McClure, C. D. Lind, D. A. Ahlquist, M. R. Pittelkow, D. C. Lee, E. P. Sandgren, D. L. Page, and R. J. J. Coffey. Possible role of transforming growth factor a in the pathogenesis of Menetrier’s disease: Supportive evidence from humans and transgenic mice. Gastroenterology 103: 1950–1963, 1992.PubMedGoogle Scholar
- 15.Higham, A. D., L. A. Bishop, R. Dimaline, C. G. Blackmore, A. C. Dobbins, A. Varro, D. G. Thompson, and G. J. Dockray. Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology 116: 1310–1318, 1999.PubMedCrossRefGoogle Scholar
- 19.Kobayashi, S., T. Akiyama, K. Nata, M. Abe, M. Tajima, N. J. Shervani, M. Unno, S. Matsuno, H. Sasaki, S. Takasawa, and H. Okamoto. Identification of a receptor for Reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. J Biol.Chem. 275: 10723–10726, 2000.PubMedCrossRefGoogle Scholar
- 26.Schultheis, P. J., L. L. Clarke, P. Meneton, M. Harline, G. P. Boivin, G. Stemmermann, J. J. Duffy, T. Doetschman, M. L. Miller, and G. E. Shull. Targeted disruption of the murine Na+/H+ Exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J.Clin.Invest. 101: 1243–1253, 1998.PubMedCrossRefGoogle Scholar
- 33.Walsh, J. H. Gastrin. In Walsh, J. H. and G. J. Dockray, eds. Gut Peptides. New York, Raven Press. 1994, 75–121.Google Scholar
- 35.Wang, T. C., C. A. Dangler, D. Chen, J. R. Goldenring, T. J. Koh, R. Raychowdhury, R. J. Coffey, S. Ito, A. Varro, G. J. Dockray, and J. G. Fox. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 118: 36–47, 2000.PubMedCrossRefGoogle Scholar