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Duodenal Protection: Influence of Melatonin and other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling

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Abstract

The duodenal epithelium secretes HC03 - at higher rates than does the stomach (or more distal small intestine) and the duodenal secretion is currently accepted as the most important defence mechanism against acid discharged from the stomach (4,6). HC03 - entering the continuous layer of visco-elastic mucus gel on top of the epithelial surface maintains pH in its cell-facing portion at neutrality at acidities encountered in the healthy duodenum.

Keywords

  • Irritable Bowel Syndrome
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Pineal Gland
  • Crypt Cell
  • Carbonic Anhydrase Activity

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Flemström, G., Sjöblom, M. (2002). Duodenal Protection: Influence of Melatonin and other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling. In: Urushidani, T., Forte, J.G., Sachs, G. (eds) Mechanisms and Consequences of Proton Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0971-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-0971-4_12

  • Publisher Name: Springer, Boston, MA

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