A Disintegrin and Metalloprotease (Adams) Family: Expression and Potential Roles in the Developing Heart

  • Thomas K. Borg
  • Angela De Almeida
  • Melissa Joy Loftis
  • Alex McFadden
  • Wayne Carver
Part of the Progress in Experimental Cardiology book series (PREC, volume 4)


The A Disintegrin And Metalloproteases (ADAMs) are a rather recently identified family of cell surface molecules which have a characteristic multidomain structure. The multiple domains found in these proteins include a metalloprotease domain that has been shown to proteolytically cleave extracellular matrix and cell surface proteins. These domains also include a disintegrin region which has been shown to participate in cell-cell binding in some cell types. Through these multiple functional domains, ADAMs have been shown to play roles in diverse developmental processes including cell-cell fusion and cell migration. The roles of these proteins in the developing cardiovascular system have not been examined. In the following discussion, we will summarize the current knowledge of these molecules in other systems and present novel data regarding their expression and potential function in the developing heart.

Key words

Disintegrin Metalloprotease Extracellular matrix Integrin 


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Thomas K. Borg
    • 1
  • Angela De Almeida
    • 1
  • Melissa Joy Loftis
    • 1
  • Alex McFadden
    • 1
  • Wayne Carver
    • 1
  1. 1.Department of Developmental Biology and Anatomy, School of MedicineUniversity of South CarolinaColumbiaUSA

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