Summary
Although the neonatal heart develops less contractile force in comparison to the adult heart, it is much more tolerant with respect to ischemia-reperfusion injury, occurrence of Ca2+-paradox and catecholamine-induced cardiotoxicity. By employing 5 day old neonatal and 250 day old adult rats, we have shown that the density of L-type Ca2+-channels as Well as the activities of sarcolemmal Na+-Ca2+ exchanger and Ca2+-pump were higher in the neonatal heart. On the other hand, basal and isoproterenol-stimulated adenylyl cyclase activities as well as sarcolemmal Na+-K+ ATPase and 3H-ouabain binding activities in the neonatal hearts were lower in comparison to the adult hearts. The immaturity of sarcoplasmic reticulum in the neonatal heart was evident from the low Ca2+-pump, Ca2+-release and 3H-ryanodine binding activities in comparison to the adult heart. While Ca2+-uptake activity in neonatal heart mitochondria was higher, mitochondrial ATPase activity was lower when compared to those in the adult heart. These data provide evidence that the Ca2+-handling abilities and regulatory mechanisms in neonatal and adult hearts are different from each other and these differences may explain the weakness of cardiac function as well as increased tolerance of the neonatal heart to different pathophysiological interventions.
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Dhalla, N.S., Ostadalova, I., Ostadal, B., Mengi, S.A., Elimban, V., Nijjar, M.S. (2002). Differences in Calcium Handling and Regulatory Mechanisms between Neonatal and Adult Hearts. In: Ostadal, B., Nagano, M., Dhalla, N.S. (eds) Cardiac Development. Progress in Experimental Cardiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0967-7_13
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DOI: https://doi.org/10.1007/978-1-4615-0967-7_13
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