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Sarcoplasmic Reticulum Function in the Developing Heart

  • Chapter
Cardiac Development

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 4))

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Summary

In view of the critical role of sarcoplasmic reticulum (SR) in regulating Ca2+-movements and thereby modulating cardiac contractility in the adult hearts, several studies have been carried out to understand its contribution in cardiac contraction and relaxation processes at early stages of myocardial development. The contractile characteristics of the neonatal heart are weak in comparison to the adult heart. Sparse sympathetic innervation and an immature SR were suggested to be factors contributing to reduced contractility of the neonatal heart. SR Ca2+-uptake and release activities as well as expression of the SR Ca2+-cycling proteins have been reported to increase after birth. The presence of protein kinases and phosphatases in early stages of development indicate a role for the regulatory mechanisms in maintaining SR Ca2+-transport. However, increased expression of phosphatases in the early stages suggest enhanced dephosphorylation of SR proteins. There is a lack of effects of Ca2+-channel inhibitors on neonatal hearts and increased Na+-Ca2+-exchanger function in the fetal and neonatal in comparison to the adult heart. Thus, in view of the reduced SR function at early stages of development, the SR does not appear to play a major role in the regulation of cardiac contractility during the fetal and neonatal stages.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Rana M. Temsah, Thomas Netticadan & Dr Naranjan S. Dhalla

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  1. Rana M. Temsah
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  2. Thomas Netticadan
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  3. Dr Naranjan S. Dhalla
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Correspondence to Naranjan S. Dhalla .

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Editors and Affiliations

  1. Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Bohuslav Ostadal M.D., D.Sc. (Professor) (Professor)

  2. Jikei University School of Medicine, Tokyo, Japan

    Makoto Nagano M.D., Ph.D. (Professor Emeritus) (Professor Emeritus)

  3. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.), D.Sc. (Hon.) (Distinguished Professor and Director) (Distinguished Professor and Director)

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Temsah, R.M., Netticadan, T., Dhalla, N.S. (2002). Sarcoplasmic Reticulum Function in the Developing Heart. In: Ostadal, B., Nagano, M., Dhalla, N.S. (eds) Cardiac Development. Progress in Experimental Cardiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0967-7_12

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