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Tetrahydrobiopterin Deficiency in Diabetic Rats

  • Cynthia J. Meininger
  • Kazuyuki Hatakeyama
  • Tony E. Haynes
  • Katherine A. Kelly
  • Guoyao Wu

Abstract

Vascular complications are major causes of morbidity and mortality in patients with insulin-dependent diabetes mellitus. Defects in the generation and release of nitric oxide (NO), the so-called endothelium-derived relaxing factor, have been implicated in the development of diabetic vasculopathy. Our previous data indicated that a deficiency in tetrahydrobiopterin (BH4), a cofactor essential for the activity of NO synthase, was responsible for reduced NO production in coronary endothelial cells of the spontaneously diabetic BB rat, an animal model of human type I diabetes mellitus (1). The BH4 deficiency was the result of decreased expression of GTP cyclohydrolase I (GTP-CH), the first and rate-limiting enzyme for the generation of BH4.

Keywords

Diabetic Animal Coronary Endothelial Cell Diabetic Vasculopathy Juvenile Diabetes Foundation Venular Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Meininger C.J., Marinos R.S., Martinez-Zaguilan R., Rojas J.D., Kelly K.A., Wu G. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J 349: 353–356, 2000.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Cynthia J. Meininger
    • 1
  • Kazuyuki Hatakeyama
    • 2
  • Tony E. Haynes
    • 3
  • Katherine A. Kelly
    • 1
  • Guoyao Wu
    • 1
    • 3
  1. 1.Cardiovascular Research Institute and Department of Medical PhysiologyThe Texas A&M University System Health Science CenterCollege StationUSA
  2. 2.Department of SurgeryUniversity of PittsburghPittsburghUSA
  3. 3.Department of Animal ScienceTexas A&M UniversityCollege StationUSA

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