Abstract
The phenomenon of circadian (~24 h) rhythms has been conserved from single cell (e.g. cyanobacteria) to complex organisms including plants and mammals. Although the output varies from one species to another, ranging from the circadian production of asexual spores in Neurospora and the circadian movement of leaves in Arabidopsis to the rest:activity rhythm in Drosophila and mammals, all circadian rhythms share some basic properties 1) They can be synchronized or entrained to environmental cues such as light or temperature. 2) They freerun in constant conditions. 3) the periodicity is temperature compensated, i.e. the period does not change over a wide range of temperature. In addition, they are all thought to be produced by a circadian system that consists of an input pathway, a central clock and an output pathway. The clock is the timekeeping component that transmits its signals to the rest of the organism through the output pathway. The input pathway serves to connect the clock to the environment, conveying signals from external stimuli such as light and temperature. Much of our current understanding of how clocks are generated in mammals is derived from research done in the fruit fly Drosophila melanogaster. This chapter will focus on the molecular mechanisms that entrain the clock to light in this organism.
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References
Konopka RJ, Benzer S. Clock mutants of Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 1971; 68:2112–2116.
Sehgal A, Price JL, Man B, Young MW. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science 1994; 263:1603–1606.
Williams JA, Sehgal A. Molecular components of the Drosophila circadian clock. Annual Review of Physiology 2001; 63:729–755.
Curtin KD, Huang ZJ, Rosbash M. Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron 1995; 14:365–72.
Gekakis N, Saez L, Delahaye BA, et al. Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science 1995; 270:811–815.
Marrus SB, Zeng H, Rosbash M. Effect of constant light and circadian entrainment of perS flies: evidence for light-mediated delay of the negative feedback loop in Drosophila. EMBO Journal 1996; 15:6877–6886.
Price JL, Blau J, Rothenflugh A, Abodeely M, Kloss B, Young MW. double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 1998; 94:83–95.
Rutila JE, Zeng H, Le M, Curtin KD, Hall JC, Rosbash M. The tim SL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron 1996; 17:921–929.
Yang Z, Sehgal A. Role of molecular oscillations in the Drosophila circadian clock. Neuron 2001; 29: 453–467.
Hunter-Ensor M, Ousley A, Sehgal A. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 1996; 84:677–86.
Lee C, Parikh V, Itsukaichi T, Bae K, Edery I. Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 1996; 271:1740–44.
Myers MP, Wager-Smith K, Rothenflugh A, Young MW. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 1996; 271:1736–40.
Zeng H, Qian Z, Myers MP, Rosbash M. A light entrainment mechanism for the Drosophila circadian clock. Nature 1996; 380:129–135.
Suri V, Zuwei Q, Hall JC, Rosbash M. Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron 1998; 21:225–234.
Yang Z, Emerson M, Su HS, Sehgal A. Response of the timeless protein to light correlates with behavioral entrainment and suggests a non-visual pathway for circadian photoreception. Neuron 1998; 21:215–223.
Frank KD, Zimmerman WF. Action spectra for phase shifts of a Drosophila circadian rhythm. Science 1969; 163:688–689.
Zuker CS. The biology of vision in Drosophila. Proc. Natl. Acad. Sci. USA 1996; 93:571–6.
Helfrich C. Role of the optic lobes in the regulation of the locomotor activity rhythm of Drosophila melanogaster-Behavioral analysis of neural mutants. Journal of Neurogenetics 1986;3:321–43.
Chen DM, Christianson JS, Sapp RJ, Stark WS. Visual receptor cycle in normal and period mutant Drosophila: microspectrophotometry, electrophysiology, and ultrastructural morphometry. Visual Neuroscience 1992; 9:125–35.
Egan E, Franklin T, Hilderbrand-Chae M, et al. An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. The Journal of Neuroscience 1999; 19:3665–3673.
Emery P, So W, Kaneko M, Hall JC, Rosbash M. CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity. Cell 1998; 95:669–679.
Ishikawa T, Matsumoto A, Kato T, Jr., et al. DCRY is a Drosophila photoreceptor protein implicated in light entrainment of circadian rhythm. Genes to Cells 1999; 4:57–65.
Stanewsky R, Kaneko M, Emery P, et al. The cry b Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila. Cell 1998; 95:681–692.
Emery P, Stanewsky R, Rosbash M, Hall JC. dCRY is a unique Drosophila circadian photoreceptor. Nature 2000; 404:456–457.
Emery P, Stanewsky R, Helfrich-Forster C, Emery-Le M, Hall JC, Rosbash M. Drosophila CRY Is a Deep Brain Circadian Photoreceptor. Neuron 2000; 26:493–504.
Helfrich-Forster C, Winter C, Hofbauer A, Hall JC, Stanewsky R. The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 2001; 30:249–261.
Hofbauer A, Buchner E. Does Drosophila have seven eyes? Naturwissenschaften 1989; 76:335–336.
Hamblen-Coyle MJ, Wheeler DA, Rutila JE, Rosbash M, Hall JC. Behavior of period-altered circadian rhythm mutants of Drosophila in light: dark cycles (Diptera: Drosophilidae). Journal of Insect Behavior 1992; 5:417–445.
Naidoo N, Song W, Hunter-Ensor M, Sehgal A. A role for the proteasome in the light response of the timeless clock protein. Science 1999; 285:1737–1741.
Ivachenko M, Stanewsky R, Giebultowicz JM. Circadian photoreception in Drosophila: Functions of cryptochrome in peripheral and central clocks. Journal of Biological Rhythms 2001; 16:205–215.
Krishnan B, Levine JD, Lynch MKS, et al. A new role for cryptochrome in a Drosophila circadian oscillator. Nature 2001; 411:313–317.
Ceriani MF, Darlington TK, Staknis D, et al. Light-Dependent Sequestration of Timeless by Cryptochrome. Science 1999; 285:553–556.
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Lin, FJ., Sehgal, A. (2002). Entrainment of the Drosophila circadian clock by light. In: Holick, M.F. (eds) Biologic Effects of Light 2001. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0937-0_42
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DOI: https://doi.org/10.1007/978-1-4615-0937-0_42
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