Abstract
Ultraviolet (UV) radiation has been used for decades in the treatment of patients with a variety of T-cell-mediated skin diseases such as atopic dermatitis. Among the different phototherapeutic modalities that are currently available recent interest has focused on the use of irradiation device that allow exposure of human skin to wavelengths in the longer UVA range, that is UVA-1 (340–400 nm) [1]. The almost complete absence of erythemogenic wavelengths shorter than 340 nm allow exposure of human skin to single doses of up to 130 J/m2. These clinical developments have stimulated studies about the mechanisms by which UVA 1 phototherapy works.
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Reference
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Heidi Plettenberg, Helger Stege, Thomas Ruzicka, Yoko Hosokawa, Takuo Tsuji, Akimichi Morita, Jean Krutmann, Ultraviolet A-1 (340–400nm) phototherapy for cutaneous T cell lymphoma, J Am Acad Dermatol, 41: 47–50, 1999.
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Morita, A., Krutmann, J. (2002). Clinical Relevance of Uva1-Induced T-Cell Apoptosis. In: Holick, M.F. (eds) Biologic Effects of Light 2001. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0937-0_31
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DOI: https://doi.org/10.1007/978-1-4615-0937-0_31
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