Abstract
The ultraviolet (UV) radiation solar spectrum that reaches the earth consists of short wavelength UVC (< 280 nm), intermediate wavelength UVB (280–320 nm) and long wavelength UVA (320–400 nm) radiation. Under physiological conditions, human cells are exclusively exposed to UVB and UVA radiation, because ozone in the stratosphere completely absorbs wavelengths < 290 nm. The amount of UVA radiation reaching the earth’s surface is approximately 20 times greater than that of UVB radiation, and solar UVA radiation contributes to photoageing and photocarcinogenesis of human skin and is responsible for triggering the most frequent photodermatoses, that is polymorphous light eruption (Urbach, 1992).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Basu-Modak, S. and Tyrrell, R.M. (1993) Singlet oxygen: A primary effector in the ultraviolet A/ near-visible light induction of the human heme oxygenase gene. Cancer Res. 53, 4505–4519.
Bauer, R., Imhof, A., Pscherer, A., Kopp, H., Moser, M., Seegers, S., Kerscher, M., Tainky, M.A., Hofstaedter, F., Buettner, R. (1994). The genomic structure of the human AP-2 transcription factor. Nucl. Acids. Res. 22, 1413–1420.
Bender, K., Blattner, C., Knebel, A., Iordanov, M., Herrlich, P., Rahmsdorf, H.J. (1997). UV-induced signal transduction. Photochem. Photobiol B 37, 1–17.
Buettner, R., Kannan, P., Imhof, A., Bauer, R., Yim, S.O.,Glockshuber, R., van Dyke, M.W., Tainsky, M.A. (1993). An alternatively spliced mRNA from the AP-2 gene enodes a negative regulator of transcriptional activation by AP-2. Mol. Cell. Biol. 13, 4174–4185.
Duan, C. and Clemmons, D.R. (1995). Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression. J. Biol. Chem. 270, 24844–24851.
Grether-Beck, S., Olaizola-Horn, S., Schmitt, H., Grewe, M., Jahnke, A., Johnson, J.P., Briviba, K., Sies, H., Krutmann, J. (1996). Activation of transcription factor AP-2 mediates UVA radiation-and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc. Natl. Acad. Sci. USA 93:14586–14591.
Felsner, I., Grether-Beck, S., Schmitt-Brenden, H., Krutmann, J. (2001) Mitochondrial cytochrome C mediates ceramide-induced gene expression in human keratinocytes through oxidation of transcription factor AP-2. 295 Abstract. Arch. Dermatol. Res. 403, 30.
Grether-Beck, S., Schmitt, H., Grewe, M., Buettner, R., Krutmann, J. (1997) The balance between expression of transcription factor AP2 and its alternative splice product AP2B controls ultraviolet A radiation (UVAR)-induced gene expression in human cells. J. Invest. Dermatol. 108, 594.
Grether-Beck, S., Bonizzi, G., Schmitt-Brenden, H., Felsner, I., Timmer, A., Sies, H., Johnson, J.P., Piette, J., Krutmann, J. (2000) Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J. 19, 5793–5800.
Karin, M., and Herrlich, P. (1989) Cis-and trans-acting elements responsible for induction of specific genes by tumor promotors, serum factors, and stress. In: Genes and Siganl Transduction in Multistage Carcinogenesis, Colburn, N.H., ed., Marcel Dekker, New York, pp. 415–440.
Kochevar, I.E. (1995). Primary processes in photobiology and photosensitation. In: Photoimmunology. Krutmann, J., and Elmets, C.A., eds. (Blackwell Science Ltd.) pp. 19–33.
Krutmann, J., Czech W, Diepgen T, Niedner R, Kapp A, Schöpf, E. (1992). High-dose UVA1 therapy in the treatment of patients with atopic dermatitis. J Am Acad Dermatol 26, 225–230.
Krutmann, J., and Grewe, M. (1995) Involvement of cytokines, DNA damage, and reactive oxygen intermediates in ultraviolet radiation-induced modulation of intercellular adhesion molecule-1 (ICAM-1) expression. J. Invest. Dermatol. 105, 67S–70S.
Morita, A., Grewe, M., Grether-Beck, S., Olaizola-Horn, S., Krutmann, J. (1997). Induction of proinflammatory cytokines in human epidermoid carcinoma cells by in vitro ultraviolet A1 irradiation. Photochem. Photobiol. 65, 630–635.
Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L.O., Sies, H., Krutmann, J. (1997) Evidence that singlet oxygen-induced human T-helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J. Exp. Med. 186, 1763–1768.
Punchard, N.A., and Kelly, F.J. (1996). Free radicals. In: Free Radicals-A practical approach eds. N.A. Punchard and F.J. Kelly. (IRL press, Oxford, New York, Tokyo) pp. 1–8.
Stege, H., Humke, S., Berneburg, M. et al., 1996. High-dose UVAl therapy in the treatment of patients with localized scleroderma (morphea). J. Am. Acad. Dermatol. 36, 938–944.
Stege H., Schöpf, E., Ruzicka, T., Krutmann, J. (1996). High-dose UVAl for urticaria pigmentosa. Lancet 347, 64.
Tyrrell, R.M. (1996). Activation of mammalian gene expression by the UV component of sunlight -from models to reality. Bioassays 18, 139–148.
Urbach, F., ed. (1992) Biological responses to ultraviolet A radiation. Valdenmar, Overland Park, Kansas.
Wlaschek, M. Briviba, K., Stricklin, G.P., Sies, H., and Scharfetter-Kochanek, K. (1995). Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J. Invest. Dermatol. 104, 194–198.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Krutmann, J., Grether-Beck, S. (2002). Ultraviolet a Radiation-Induced Signal Transduction in Human Keratinocytes. In: Holick, M.F. (eds) Biologic Effects of Light 2001. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0937-0_29
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0937-0_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5313-3
Online ISBN: 978-1-4615-0937-0
eBook Packages: Springer Book Archive