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Theileria pp 1–22Cite as

Theileria Development and Host Cell Invasion

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Part of the book series: World Class Parasites ((WCPA,volume 3))

Abstract

Theileria are tick-transmitted, obligate intracellular parasites that are important pathogens of livestock in the Old World tropical and subtropical regions. Like all intracellular organisms, host cell invasion is a critical aspect of Theileria biology and the various invasive stages (the sporozoite and merozoite in the mammalian host, the zygote and kinete in the tick vector) are highly adapted to invade and survive in their specific host cells in both the vertebrate and tick hosts.

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References

  • Berger, E.A., P.M. Murphy, and J.M. Farber. 1999. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease. Annual Review of Immunology 17, 657–700.

    Article  PubMed  CAS  Google Scholar 

  • Blackman, M.J., and L.H. Bannister. 2001. Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation. Molecular and Biochemical Parasitology 117, 11–25.

    Article  PubMed  CAS  Google Scholar 

  • Briones, M.R.S., M. Tsuji, and V. Nussenzweig. 1996. The large differences in infectivity for mice of Plasmodium berghei and Plasmodium yoelii sporozoites cannot be correlated with their ability to enter into hepatocytes. Molecular and Biochemical Parasitology 77, 7–17.

    Article  PubMed  CAS  Google Scholar 

  • Dubremetz, J.F., N. Garcia-R guet, V. Conseil, and M.N. Fourmaux. 1998. Apical organelles and host-cell invasion by Apicomplexa. International Journal for Parasitology 28, 1007–1013.

    Article  PubMed  CAS  Google Scholar 

  • Ebel, T., J. Gerhards, B.R. Binder, and J. Lipp. 1999. Theileria parva 104 kDa microneme-rhoptry protein is membrane anchored by a non-cleaved amino-terminal signal sequence for entry into the endoplasmic reticulum. Molecular and Biochemical Parasitology 100, 19–26.

    Article  PubMed  CAS  Google Scholar 

  • Fawcett, D.W., P.A. Conrad, J.G. Grootenhuis, and S.P. Morzaria. 1987. Ultrastructure of the intra-erythrocytic stage of Theileria species from cattle and waterbuck. Tissue and Cell 19, 643–655.

    Article  PubMed  CAS  Google Scholar 

  • Gough, J.M., W.K. Jorgensen, and D.H. Kemp. 1998. Development of tick gut forms of Babesia bigemina in vitro. Journal of Eukaryotic Microbiology 45, 298–306.

    Article  PubMed  CAS  Google Scholar 

  • Hagiwara, K., T. Ichikawa, and M. Takahashi. 1996. Studies on an experimental system for the invasion of Theileria sergenti merozoite into erythrocytes. Veterinary Parasitology 63, 187–193.

    Article  PubMed  CAS  Google Scholar 

  • Hagiwara, K., M. Takahashi, T. Ichikawa, M. Tsuji, K. Ikuta, and C. Ishihara. 1997. Inhibitory effort of heparin on red blood cell invasion by Theileria sergenti merozoites. International Journal for Parasitology 27, 535–539.

    Article  PubMed  CAS  Google Scholar 

  • Han, Y.S, J. Thompson, F.C. Kafatos, and C. Barillas-Mury. 2000. Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei. the time bomb theory of ookinete invasion of mosquitoes. EMBO Journal. 19, 6030–6040.

    Article  PubMed  CAS  Google Scholar 

  • Kamwendo, S.P., G.A. Ingram, F.L. Musisi, A.J. Trees, and D.H. Molyneux. 1993. Characteristics of tick, Rhipicephalus appendiculatus, glands distinguished by surface lectin binding. Annuals of Tropical Medicine and Parasitology 87, 525–535.

    CAS  Google Scholar 

  • Kappe, S., T. Bruderer, S. Gantt, H. Fujioka, V. Nussenzweig, and R. M nard. 1999. Conservation of a gliding motility and cell invasion machinery in apicomplexan parasites. Journal of Cell Biology 147, 937–943.

    Article  PubMed  CAS  Google Scholar 

  • Kaslow, D.C. 1996. Transmission-blocking vaccines. In Malaria Vaccine Development: A Multi-immune Response Approach, S.L. Hoffman (ed.), ASM Press, Washington, D.C., p. 181–227.

    Google Scholar 

  • Langer, R. C, and J.M. Vinetz. 2001. Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix. Trends in Parasitology 17, 269–272.

    Article  PubMed  CAS  Google Scholar 

  • Mehlhorn, H., E. Schein, and J.S. Ahmed. 1994. Theileria. In Parasitic Protozoa, volume 7, pp. 217–304, J.P. Kreier (ed.). Academic Press.

    Google Scholar 

  • M nard, R. 2001. Gliding motility and cell invasion by Apicomplexa: insights from the Plasmodium sporozoite. Cellular Microbiology 3, 63–73.

    Article  Google Scholar 

  • M nard, R., A.A. Sultan, C. Cortes, R. Altszuler, M.R. Dijk, C.J. Janse, A.P. Waters, R.S. Nussenweig, and V. Nussenzweig. 1997. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385, 336–340

    Article  Google Scholar 

  • Morrison, W.I., N.D. MacHugh, and P.A. Lalor. 1996. Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite. Infection and Immunity 64, 557–562

    PubMed  CAS  Google Scholar 

  • Mota M.M., G. Pradel, J.P. Vanderberg, J.C.R. Hafalla, U. Frevert, R.S. Nussenzweig, V. Nussenzweig, and A. Rodriguez. 2001. Migration of Plasmodium sporozoites through cells before infection. Science 291, 141–144.

    Article  PubMed  CAS  Google Scholar 

  • Norval, R.A.I., B.D. Perry, and A.S. Young. 1992. The Epidemiology of Theileriosis in Africa. Academic Press, London.

    Google Scholar 

  • Ochanda, H., A.S. Young, C. Wells, G.F. Medley, and B.D. Perry. 1996. Comparison of the transmission of Theileria parva between different instars of Rhipicephalus appendiculatus. Parasitology 113, 243–253.

    Article  PubMed  Google Scholar 

  • Pinzon-Ortiz, C, J. Friedman, J. Ksko, and P. Sinnis. 2001. The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for Plasmodium sporozoite attachment to target cells. Journal of Biology Chemistry 276, 26784–26791.

    Article  CAS  Google Scholar 

  • Rudzinska M.A., S. Lewengrub, A. Spielman, and J. Piesman. 1983. Invasion of Babesia microti into epithelial cells of the tick gut. Journal of Protozoology 30, 338–346.

    PubMed  CAS  Google Scholar 

  • Shakibaei, M., and U. Frevert. 1996. Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans. Journal of Experimental Medicine 184, 11699–1717.

    Article  Google Scholar 

  • Shaw, M.K. 1997. The same but different: the biology of Theileria sporozoite entry into bovine cells. International Journal for Parasitology 27, 457–474.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, M.K., L.G. Tilney, and A.J. Musoke. 1991. The entry of Theileria parva sporozoites into bovine lymphocytes: evidence for MHC class I involvement. Journal of Cell Biology 113, 87–101.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, M.K., and L.G. Tilney. 1992. How individual cells develop from a syncytium: merogony in Theileria parva (Apicomplexa). Journal of Cell Science 101, 109–123.

    PubMed  Google Scholar 

  • Shaw, M.K., L.G. Tilney, and D.J. McKeever. 1993. Tick salivary gland extract and interleukin-2 stimulation enhances susceptibility of lymphocytes to infection by Theileria parva sporozoites. Infection and Immunity 61, 1486–1495

    PubMed  CAS  Google Scholar 

  • Shaw, M.K., and A.S. Young. 1994. The biology of Theileria species in ixodid ticks in relation to parasite transmission. Advances in Disease Vector Research 10, 23–63.

    Article  Google Scholar 

  • Shaw, M.K., and L.G. Tilney. 1995. The entry of Theileria parva merozoites into bovine erythrocytes occurs by a process similar to sporozoite invasion of lymphocytes. Parasitology 111, 455–461.

    Article  PubMed  Google Scholar 

  • Shaw, M.K., D.S. Roos, and L.G. Tilney. 2001. DNA replication and daughter cell budding are not tightly linked in the protozoan parasite Toxoplasma gondii. Microbes and Infection 3, 351–362.

    Article  PubMed  CAS  Google Scholar 

  • Shiels, B.R. 1999. Should I stay or should I stay? A stochastic model of stage differentiation in Theileria annulata. Parasitology Today 15, 241–245.

    Article  PubMed  CAS  Google Scholar 

  • Silvestrini, F., P. Alano, and J.L. Williams. 2000. Commitment to the production of male and female gametocytes in the human malaria parasite Plasmodium falciparum. Parasitology 121, 465–471.

    Article  PubMed  Google Scholar 

  • Sinden, R.E., G.A. Butcher, O. Billker, and S.L. Fleck. 1996. Regulation of infectivity of Plasmodium to the mosquito vector. Advances in Parasitology 38, 53–117.

    Article  PubMed  CAS  Google Scholar 

  • Sinden, R.E. 1998. Gametocytes and sexual development. In Malaria. Parasite Biology, Pathogenesis and Protection, I.W. Sherman (ed.). ASM Press, Washington D.C. pp. 25–48.

    Google Scholar 

  • Skilton, R.A., R.P. Bishop, C.W. Wells, P.R. Spooner, E. Gobright, C. Nkonge, A.J. Musoke, M. Macklin, and K.P. lams. 1999. Cloning and characterization of a 150 kDa microsphere antigen of Theileria parva that is immunologically cross-reactive with the polymorphic immunodominant molecule (PIM). Parasitology 117, 321–330.

    Article  Google Scholar 

  • Skilton, R.A., A.J. Musoke, V. Nene, D.P.S. Wasawo, C.W. Wells, P.R. Spooner, R.P. Bishop, J. Osaso, C. Nkonge, A. Latif, and S.P. Morzaria. 2000. Molecular characterization of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen. Molecular and Biochemical Parasitology 107, 309–314.

    Article  PubMed  CAS  Google Scholar 

  • Sonenshine, D.E. 1991. Biology of Ticks. Volume 1. Oxford University Press, New York & Oxford.

    Google Scholar 

  • Tomas, A.M., G. Margos, G. Dimopoulos, L.H.M. van Lin, T.F. Koning-Ward, R. Sinha, P. Lupetti, A.L. Beetsma, M.C. Rodriguez, M. Karras, G.A. Butcher, F. Kafatos, C.J. Janse, A.P. Waters, and R.E. Sinden. 2001. P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions. EMBO Journal 20, 3975–3983.

    Article  PubMed  CAS  Google Scholar 

  • Tomley, F.M., and D.S. Soldati. 2001. Mix and match modules: structure and function of microneme proteins in apicomplexan parasites. Trends in Parasitology 17, 81–88.

    Article  PubMed  CAS  Google Scholar 

  • Toye, P.G., B.M. Goddeeris, K. lams, A.J. Musoke, and W.I. Morrison. 1991. Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva. Parasite Immunology 13, 49–62.

    Article  PubMed  CAS  Google Scholar 

  • Vandenberg, J.P., R.S. Nussenzweig, and H. Most. 1968. Further studies on the Plasmodium berghei-Anopheles stephensi-rodent system of mammalian malaria. Journal of Parasitology 54, 1009–1016.

    Article  Google Scholar 

  • Waladde, S.M., A.S. Young, S.N. Mwaura, G.N. Njihia, and F.N. Mwakima. 1995. Optimization of the in vitro feeding of Rhipicephalus appendiculatus nymphae for the transmission of Theileria parva. Parasitology 111, 463–468.

    Article  PubMed  Google Scholar 

  • Ying, P., M. Shakibaei, M.S. Patankar, P. Clavijo, R.C. Beavis, G.F. Clark, and U. Frevert. 1997. The malaria circumsporozoite protein: interaction of the conserved regions I and II-plus with heparin-like oligosaccharides in heparan sulfate. Experimental Parasitology 85, 168–182.

    Article  PubMed  CAS  Google Scholar 

  • Young, A.S., T.T. Dolan, S.P. Morazaria, F.N. Mwakima, R.A.I. Norval, J. Scott, A. Sherriff, and G. Gettenby. 1996. Factors influencing infections in Rhipicephalus appendiculatus ticks fed on cattle infected with Theileria parva. Parasitology 113, 255–266.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, Manchester, UK

    Michael K. Shaw

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  1. Michael K. Shaw
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Editors and Affiliations

  1. University of Bern, Switzerland

    Dirk A. E. Dobbelaere

  2. University of Edinburgh, Roslin, Midlothian, UK

    Declan J. McKeever

  3. Moredun Research Institute, Penicuik, Midlothian, UK

    Declan J. McKeever

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© 2002 Springer Science+Business Media New York

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Shaw, M.K. (2002). Theileria Development and Host Cell Invasion. In: Dobbelaere, D.A.E., McKeever, D.J. (eds) Theileria. World Class Parasites, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0903-5_1

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  • DOI: https://doi.org/10.1007/978-1-4615-0903-5_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5296-9

  • Online ISBN: 978-1-4615-0903-5

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