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Immunobiology of Hepatitis Viruses

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Hepatitis Viruses

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Abstract

Hippocrates described the existence of agents capable of causing epidemic jaundice as early as 400BC. Further outbreaks of catarrhal jaundice during World War II, the distinction of “infectious” and “serum” hepatitis by Krugman, the discovery of the Australia antigen by Blumberg and colleagues and the identification of hepatitis C virus (HCV) as the major cause of posttransfusion hepatitis by Houghton have resulted in vast increases in our knowledge of viral hepatitis. Intense research into the molecular structures, biological life cycles, and mechanisms of disease has occurred over the past 30 years (1, 2). Researchers have made full use of epidemiological studies, clinical research trials and technologies such as animal models, tissue culture and human studies to develop sensitive and specific diagnostics tests, effective antiviral therapies and in the cases of hepatitis A and B viruses, (HAV, HBV) safe and effective vaccines. Despite the wealth of knowledge regarding the molecular biology of the viruses and the medical importance of the disease, the interactions between the immune system and hepatitis viruses, and mechanisms of viral persistence are not completely understood, largely because of in-efficient or non-existent culture systems for viral propagation and absence of reagents for analysis of the immune responses in existing animal models.

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Authors and Affiliations

  1. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA

    Michael P. Curry (Hepatology Fellow)

  2. Department of Infectious Diseases, Beth Israel Deaconess Medical Center,, Harvard Medical School, Boston, MA, 02215, USA

    Margaret James Koziel (Staff Physician, Associate Professor of Medicine)

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  1. Michael P. Curry
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  1. University of Southern California, USA

    J.-H. James Ou

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Curry, M.P., Koziel, M.J. (2002). Immunobiology of Hepatitis Viruses. In: Ou, JH.J. (eds) Hepatitis Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0881-6_8

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