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The Molecular Biology of Hepatitis C Virus

  • Chapter
Hepatitis Viruses

Abstract

Despite the decreased incidence of post-transfusion hepatitis caused by hepatitis C virus (HCV), this chronic viral infection remains a major health concern affecting an estimated 170 million individuals worldwide. The acute phase of HCV infection is generally subclinical, however, approximately 80% of infected individuals fail to clear the virus and develop persistent infections. Although this may result in a healthy carrier state, a high proportion develop chronic liver disease and ∼20-30% of chronic carriers progress to cirrhosis. HCV-associated end-stage liver disease is now the leading cause for liver transplantation in the United States, and moreover HCV infection has been epidemiologically linked to the development of hepatocellular carcinoma. There is no vaccine to prevent hepatitis C infection. Prolonged treatment of chronically HCV-infected patients with interferon-α (IFN-α) alone, or in combination with the nucleoside analogue ribavirin is the only currently approved therapy, although poor response rates often accompany these treatment regimens.

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Authors and Affiliations

  1. Center for the Study of Hepatitis C, The Rockefeller University, Box 64, 1230 York Avenue, New York, NY, 10021, USA

    Keril J. Blight, Arash Grakoui, Holly L. Hanson & Charles M. Rice

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  1. Keril J. Blight
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  2. Arash Grakoui
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  3. Holly L. Hanson
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  4. Charles M. Rice
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Editors and Affiliations

  1. University of Southern California, USA

    J.-H. James Ou

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Blight, K.J., Grakoui, A., Hanson, H.L., Rice, C.M. (2002). The Molecular Biology of Hepatitis C Virus. In: Ou, JH.J. (eds) Hepatitis Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0881-6_4

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  • DOI: https://doi.org/10.1007/978-1-4615-0881-6_4

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  • Print ISBN: 978-1-4613-5285-3

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