Abstract
In searching for pathogens, T cells migrate continuously between blood and lymph through defined regions of the secondary lymphoid tissues.1 Prior to contact with antigen, T cells are maintained in a quiescent state and rarely divide.2,3 These “virgin” (naive) cells comprise the vast majority of T cells in young life and display a resting phenotype typified by low expression of CD44. With exposure to foreign antigens, specifically-reactive naive CD44lo T cells respond to these antigens and differentiate into T cells with an activated/memory CD44hi phenotype.3-8 At a population level, CD44hi T cells are presumed to carry immunological memory for a wide variety of commonly-encountered environmental antigens. In addition, some memory-phenotype CD44hi T cells may represent the progeny of naive T cells responding to self antigens.9 This process, termed homeostatic expansion of T cells, is prominent when T cell numbers are reduced, e.g. after irradiation, but is generally inconspicuous in normal animals.
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Sprent, J., Judge, A.D., Zhang, X. (2002). Cytokines and Memory-Phenotype Cd8+ Cells. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_20
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DOI: https://doi.org/10.1007/978-1-4615-0757-4_20
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