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Abstract

T cells in animals have several unexpected properties. The work described here concerns two of these properties. The first property to be discussed concerns the fact that T cells divide in the apparent absence of antigen when transferred to T cell deficient mice. The second investigates the finding that memory T cells contain very large amounts of mRNA for certain chemokines. These two phenomena will be discussed in separate sections below.

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References

  1. B. Rocha, N. Dautigny, and P. Pereira, Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo.EurJImmunol19 (5), 905–11 (1989).

    CAS  Google Scholar 

  2. W. C. Kieper and S. C. Jameson, Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands.Proc Natl Acad Sci U SA96 (23), 13306–11 (1999).

    Article  CAS  Google Scholar 

  3. B. Ernst, D. S. Lee, J. M. Chang, J. Sprent and C. D. Surh, The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery.Immunity11 (2), 173–81 (1999).

    Article  CAS  PubMed  Google Scholar 

  4. S. R. Clarke and A. Y. Rudensky, Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes.J Immunol165 (5), 2458–64 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. A. W. Goldrath, L. Y. Bogatzki and M. J. Bevan, Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation.JExp Med192 (4),557–64 (2000).

    Article  CAS  Google Scholar 

  6. K. S. Schluns, W. C. Kieper, S. C. Jameson and L. Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo.Nat Immunol 1(5), 426–32 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. W. C. Kieper, M. Prlic, M., C. S. Schmidt, M. F. Mescher and S. C. Jameson, IL-12 enhances CD8 T cell homeostatic expansion.Jlmmunol166 (9), 5515–21 (2001).

    Article  CAS  Google Scholar 

  8. O. Annacker, et al. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10.Jlmmuno1166 (5), 3008–18 (2001).

    Google Scholar 

  9. A. Vella, T. K. Teague, J. Ihle, J. Kappler and P. Marrack, Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4.JExp Med186 (2), 325–30 (1997).

    Article  CAS  Google Scholar 

  10. M. V. Soares, et al. IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.Jlmmunol161 (11), 5909–17 (1998).

    CAS  Google Scholar 

  11. T. E. Boursalian, T. E. and K. Bottomly, Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. Jlmmunol 162 (7), 3795–801 (1999).

    CAS  Google Scholar 

  12. T. Brocker, Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells.JExp Med 186(8), 1223–32 (1997).

    Article  CAS  Google Scholar 

  13. J. Kirberg, A. Berns and H. von Boehmer, Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.JExp Med 186(8), 1269–75 (1997).

    Article  CAS  Google Scholar 

  14. D. Nesic, D. and S. Vukmanovic, MHC classIis required for peripheral accumulation of CD8+ thymic emigrants.Jlmmunol 160(8), 3705–12 (1998).

    CAS  Google Scholar 

  15. J. Bender, T. Mitchell, J. Kappler, J. and P. Marrack, CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection.JExp Med 190(3), 367–74 (1999).

    Article  CAS  Google Scholar 

  16. C. Viret, F. S. Wong and C. A. Janeway Jr. Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition.Immunity 10(5), 559–68 (1999).

    Article  CAS  PubMed  Google Scholar 

  17. B. K. Cho, V. P. Rao, Q. Ge, H. N. Eisen and J. Chen, Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.J Exp Med 192 (4)549–56 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. K. Murali-Krishna, K. and R. Ahmed, Cutting edge: naive T cells masquerading as memory cells.Jlmmunol 165(4), 1733–7 (2000).

    Article  CAS  Google Scholar 

  19. D. Cosgrove, et al. Mice lacking MHC class II molecules.Cell 66(5), 1051–66 (1991).

    Article  CAS  PubMed  Google Scholar 

  20. E. K. Bikoff, et al. Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.JExp Med 177(6), 1699–712 (1993).

    Article  CAS  Google Scholar 

  21. Y. Shinkai, et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.Cell 68(5), 855–67 (1992).

    Article  CAS  PubMed  Google Scholar 

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© 2002 Springer Science+Business Media New York

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de Souza, A.R., Swanson, B., Robertson, J., Bender, J., Kappler, J., Marrack, P. (2002). Some Properties of T Cells in Animals. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_16

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  • DOI: https://doi.org/10.1007/978-1-4615-0757-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5226-6

  • Online ISBN: 978-1-4615-0757-4

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