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Lymphocyte Activation and Immune Regulation IX pp 113–120Cite as

Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 512))

Abstract

Over the past few years several studies have influenced how we think about the generation and persistence of T cell memory. First, our studies have shown that CD4 memory T cells can be derived from effector cells, without further division.1,2This implies that the differentiation events that are heritable and accompanied by epigenetic remodeling, all take place during the effector generation stage. Our results and those from Bradley’s laboratory, further indicate that an important component of memory generation from effectors is the removal of antigen and cytokines which causes this transition.2,3.

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Authors and Affiliations

  1. ‑Trudeau Institute, Saranac Lake, New York, 12983, USA

    Susan L. Swain, Javed N. Agrewala, Deborah Brownand & Deborah Brownand

Authors
  1. Susan L. Swain
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  2. Javed N. Agrewala
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  3. Deborah Brownand
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Editor information

Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. Stanford University School of Medicine, Stanford, California, USA

    Eugene Butcher

  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    William Paul

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© 2002 Springer Science+Business Media New York

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Swain, S.L., Agrewala, J.N., Brownand, D. (2002). Regulation of Memory Cd4 T Cells: Generation, Localization and Persistence. In: Gupta, S., Butcher, E., Paul, W. (eds) Lymphocyte Activation and Immune Regulation IX. Advances in Experimental Medicine and Biology, vol 512. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0757-4_15

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  • DOI: https://doi.org/10.1007/978-1-4615-0757-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5226-6

  • Online ISBN: 978-1-4615-0757-4

  • eBook Packages: Springer Book Archive

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