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Human Heme Oxygenase Gene Transfer Promotes Body Growth and Normalizes Blood Pressure in Spontaneously Hypertensive Rats Without Affecting Sprague-Dawley Rats

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Heme Oxygenase in Biology and Medicine

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Abstract

HO catalyzes the conversion of heme to bilirubin, free iron and CO. As the key enzyme in heme degradation, HO activity governs cellular heme concentration. Heme is ubiquitous and of vital importance in eukaryotes, functioning as the prosthetic moiety of various heme proteins including CYP, COX, thromboxane and prostacyclin synthases, NOS, catalase, peroxidase, and hemoglobin. Excess release of heme from myoglobin and hemoglobin has been shown to be highly toxic to several organs including the kidney. In view of the widespread utilization of heme and its potential toxicity,1 it is not surprising that tissues that normally process relatively large amounts of heme possess the biochemical means to efficiently and safely degrade the heme ring and regulate heme availability for essential functions.

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  1. Director of Gene Therapy, New York Medical College, Valhalla, New York, 10595, USA

    Nader G. Abraham

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  1. Liming Yang
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  2. Shuo Quan
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  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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Yang, L., Quan, S., Abraham, N.G. (2002). Human Heme Oxygenase Gene Transfer Promotes Body Growth and Normalizes Blood Pressure in Spontaneously Hypertensive Rats Without Affecting Sprague-Dawley Rats. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_43

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_43

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