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Heme Oxygenase in Biology and Medicine pp 43–54Cite as

Endogenous Carbon Monoxide has Protective Roles in Neointimal Development Elicited by Arterial Injury

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Abstract

The accumulation of vascular smooth muscle cells (VSMCs) in neointima resulting from the migration and proliferation of medial VSMCs in response to end-othelial damage is believed to be one of the main events involved in the initiation of atherosclerosis. Although various types of growth factor and cytokines, including endothelin-1 (ET-1), platelet-derived growth factor-B (PDGF-B) and angiotensin II (Ang II), have been acknowledged to contribute generally to the development of atherosclerosis, recent studies have indicated that many species of oxidants can be considered to be early growth signals.1,2

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Authors and Affiliations

  1. Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan, 350-0495

    Toshisuke Morita MD, Ph.D. & Shigehiro Katayama

  2. First Department of Internal Medicine, Toho University, School of Medicine, Tokyo, 143-8540, Japan

    Yuko Togane & Jun-ichi Yamazaki

  3. Department of Biochemistry and Integrative Medical Biology School of Medicine, Keio University, Tokyo, 160-8582, Japan

    Makoto Suematsu

Authors
  1. Toshisuke Morita MD, Ph.D.
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  2. Yuko Togane
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  3. Makoto Suematsu
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  4. Jun-ichi Yamazaki
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  5. Shigehiro Katayama
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Correspondence to Toshisuke Morita MD, Ph.D. .

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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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© 2002 Springer Science+Business Media New York

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Morita, T., Togane, Y., Suematsu, M., Yamazaki, Ji., Katayama, S. (2002). Endogenous Carbon Monoxide has Protective Roles in Neointimal Development Elicited by Arterial Injury. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5219-8

  • Online ISBN: 978-1-4615-0741-3

  • eBook Packages: Springer Book Archive

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