Abstract
Cardiac anaphylaxis has been described as the increase in rate and strength of contraction and the onset of arrhythmias in isolated heart preparations from sensitised animals challenged in vitro with specific antigen. These changes in myocardial functions were explained by the release of histamine as the sole mediator,1 or by the combination of histamine release with the production of vasoactive products from the arachidonic acid cascade.2 Cardiac anaphylaxis is widely recognised as an example of type I hypersensitivity in which the release of histamine participates in myocardial damage.2 Endogenous autacoids modulate cardiac anaphylaxis. In the isolated guinea pig heart, catecholamine levels and the availability of catecholamine receptors regulate the release of histamine from sensitised hearts: depletion of catecholamines and the blockade of β-receptors decrease anaphylactic histamine release, which is enhanced by noradrenaline.1 Histamine down-regulates the anaphylactic release of histamine from sensitised guinea pig hearts: H2-receptor agonists decrease the amount of histamine released, whereas cimetidine increases it.3 It has been reported that nitric oxide (NO) modulates cardiac anaphylaxis.4 The NO donor, sodium nitroprusside, decreases anaphylactic histamine release from sensitised guinea pig hearts, which is increased by blocking nitric oxide synthase.4 Relaxin (RLX) is a peptide hormone secreted mainly by the corpus luteum during pregnancy,5 with well established effects on the female reproductive organs. Cardiomyocytes from rat atria have been shown to secrete detectable amounts of RLX suggesting the cardiovascular system as a physiological target.6
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References
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© 2002 Springer Science+Business Media New York
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Vannacci, A. et al. (2002). Generation of Nitric Oxide and Carbon Monoxide Provide Protection Against Cardiac Anaphylaxis. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_38
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DOI: https://doi.org/10.1007/978-1-4615-0741-3_38
Publisher Name: Springer, Boston, MA
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