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Anti-Atherogenic Properties of Heme Oxygenase

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Heme Oxygenase in Biology and Medicine

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Abstract

Recent advances in molecular biology and transgenic techniques have led us to better understand the mechanisms of atherosclerosis (Ross, 1999; Lusis, 2000). Oxidative modification of lipoproteins in vascular wall has been considered to trigger the initiation and development of atherosclerosis (Halliwell, 1994; Thomas, 2000; Tomasian et al., 2000). To inhibit these oxidative processes, exogenous antioxidants such as vitamin E and vitamin C or endogenous enzymes such as superoxide dismutase, catalase and glutathione peroxidases have been challenged in various experimental studies and mega-clinical trials. However, since clinical benefits elicited from these antioxidants have been inconsistent (Steinberg, 1995; Yusuf et al., 2000; Stephens et al., 1996), more potent and reliable antioxidants which reduce vascular events, are desired at present.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima-city, Fukushima, 960-1295, Japan

    Kazunobu Ishikawa

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  1. Kazunobu Ishikawa
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  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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© 2002 Springer Science+Business Media New York

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Ishikawa, K. (2002). Anti-Atherogenic Properties of Heme Oxygenase. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_25

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5219-8

  • Online ISBN: 978-1-4615-0741-3

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