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Induction of Heme Oxygenase-1 as a Protective Response Against Heme Protein-Induced Renal Injury

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Heme Oxygenase in Biology and Medicine

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Abstract

The recognition that heme oxygenase (HO) activity is induced when tissues are exposed to heme and other insults raised the question of the functional significance of such induction.1–4 Evidence attesting to the cytoprotective effects of such induction of HO was first presented in the glycerol model of acute renal failure wherein the kidney is exposed acutely to a large burden of heme proteins originating from damaged skeletal muscle and red blood cells;5 examination of the induction of HO-1 in this disease model was predicated, in part, on the recognized toxicity of heme when present in inordinate amounts in tissues.6

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Author information

Authors and Affiliations

  1. Department of Pediatric and Adolescent Medicine, Mayo Clinic/Foundation, Rochester, MN, USA

    Siobhan T. Pittock

  2. Division of Nephrology, Mayo Clinic/Foundation, Rochester, MN, USA

    Karl A. Nath

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  1. Siobhan T. Pittock
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  2. Karl A. Nath
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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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Pittock, S.T., Nath, K.A. (2002). Induction of Heme Oxygenase-1 as a Protective Response Against Heme Protein-Induced Renal Injury. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_20

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_20

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