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Heme Oxygenase in Biology and Medicine pp 193–204Cite as

Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia

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Abstract

Acute hypoxia in the lung causes arteriolar vasoconstriction whereas prolonged hypoxia promotes proliferation and migration of vascular smooth muscle cells (VSMC) and extracellular matrix deposition in the arterial wall, a process known as vascular remodeling.1 These abnormalities are characteristic of pulmonary hypertension.2 Several clinical conditions characterized by lung inflammation have been linked to the development of chronic pulmonary hypertension.3 Interestingly, perivascular inflammatory cell infiltration as well as increased serum levels of pro-inflammatory cytokines, such as interleukin (IL)-lβ and IL-6, have been reported in clinical cases of primary pulmonary hypertension.4-5 However, little attention has been given up to now to the role of pulmonary inflammation in the pathogenesis of pulmonary hypertension induced by hypoxia.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Newborn Medicine, Children’s Hospital and Department of Pediatrics, Harvard Medical School Boston, Massachusetts, 02115, USA

    Stella Kourembanas M.D., Tohru Minamino, Helen Christou, Yuxiang Liu, Vijender Dhawan, Laura Atwater & S. Alex Mitsialis

  2. Program of Developmental Cardiovascular Biology the Cardiovascular Division, New York Medical College, Valhalla, NY, 10595, USA

    Chung-Ming Hsieh & Mark A. Perrella

  3. Department of Pharmacology, New York Medical College, Valhalla, NY, 10595, USA

    Nader G. Abraham

  4. Pulmonary and Critical Care Division, Brigham & Women’s Hospital, Boston, MA, 02115, USA

    Mark A. Perrella

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  1. Stella Kourembanas M.D.
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  2. Tohru Minamino
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  8. Nader G. Abraham
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Correspondence to Stella Kourembanas M.D. .

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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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Kourembanas, S. et al. (2002). Targeted Expression of Heme Oxygenase-1 and Pulmonary Responses to Hypoxia. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_16

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5219-8

  • Online ISBN: 978-1-4615-0741-3

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