Abstract
Although multiple cellular pathways may determine the fate of central nervous system neurons, the opportunity to prevent the progression of neuronal injury once initiated exists within specific time constraints. To this end, it becomes crucial to elucidate the underlying cellular and molecular mechanisms that determine neuronal injury. Generation of the free radical nitric oxide (NO) is considered to be one of the “triggers” for the subsequent induction of neuronal injury. Enhanced expression of the enzyme responsible for NO production, nitric oxide synthase (NOS), has been associated with both chronic neuronal and vascular degeneration (de la Monte et al., 2000). Underlying cellular mechanisms responsible for the detrimental effects of NOS may be related to mitochondrial energy reserves (Almeida and Bolanos, 2001).
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Maiese, K., Lin, SH., Chong, Z.Z. (2002). Early Molecular Mechanisms for the Induction of Neuronal Membrane Asymmetry and Genomic DNA Cleavage. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_13
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