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Heme Oxygenase-1 and Alzheimer Disease

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Heme Oxygenase in Biology and Medicine

Abstract

Alzheimer disease (AD) is a dementing illness characterized by progressive neuronal degeneration, gliosis, and the accumulation of intracellular inclusions (neurofibrillary tangles) and extracellular deposits of amyloid (senile plaques) in discrete regions of the basal forebrain, hippocampus, and association cortices (Selkoe, 1991). Sporadic AD is more common than all other aging-related neurodegenerative disorders combined, affecting approximately 5–10% of North Americans aged 65 and as many as 30–50% of those who survive to the end of their ninth decade (Katzman, 1993).

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Authors and Affiliations

  1. Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, McGill University, 3755 Cote St. Catherine Road Montreal, Quebec, Canada, H3T 1E2

    Yogesh Mawal, Daniel Berlin, Steven Kravitz & Hyman M. Schipper

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  1. Yogesh Mawal
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  2. Daniel Berlin
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  3. Steven Kravitz
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  4. Hyman M. Schipper
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Editors and Affiliations

  1. New York Medical College, Valhalla, New York, USA

    Nader G. Abraham

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Mawal, Y., Berlin, D., Kravitz, S., Schipper, H.M. (2002). Heme Oxygenase-1 and Alzheimer Disease. In: Abraham, N.G. (eds) Heme Oxygenase in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0741-3_12

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  • DOI: https://doi.org/10.1007/978-1-4615-0741-3_12

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