Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS)
Nitric oxide (NO) has been implicated as a potential contributor to neural cell death in a variety of neurological conditions. Glial cells in the CNS can produce nitric oxide in response to cytokines, and it is known that neurons, which are characterized by low levels of natural antioxidants and free radical scavengers, are more susceptible to oxidative damage. Heme oxygenase-1 (HO-1) is a cellular stress protein (HSP32) which is expressed in several tissues upon stimulation by a large number of potentially noxious stimuli, including oxidative stress. Activation of HO-1, generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.
KeywordsIschemia Urea Glutathione Fluoride Superoxide
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