Differential Expression of Heme Oxygenase-1 in Rat Brain by Endotoxin (LPS)

  • G. Scapagnini
  • A. M. Giuffrida Stella
  • N. G. Abraham
  • D. Alkon
  • V. Calabrese


Nitric oxide (NO) has been implicated as a potential contributor to neural cell death in a variety of neurological conditions. Glial cells in the CNS can produce nitric oxide in response to cytokines, and it is known that neurons, which are characterized by low levels of natural antioxidants and free radical scavengers, are more susceptible to oxidative damage. Heme oxygenase-1 (HO-1) is a cellular stress protein (HSP32) which is expressed in several tissues upon stimulation by a large number of potentially noxious stimuli, including oxidative stress. Activation of HO-1, generating the vasoactive molecule carbon monoxide and the potent antioxidant bilirubin, could represent a protective system potentially active against brain oxidative injury.


Nitric Oxide Nitric Oxide Heme Oxygenase Arginase Activity Antioxidant Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • G. Scapagnini
    • 1
    • 3
  • A. M. Giuffrida Stella
    • 1
  • N. G. Abraham
    • 2
  • D. Alkon
    • 3
  • V. Calabrese
    • 1
    • 3
    • 4
  1. 1.Section of Biochemistry & Mol. Biology Faculty of Medicine, Dept. of ChemistryUniversity of CataniaItaly
  2. 2.Dept. of PharmacologyNY Medical CollegeValhallaUSA
  3. 3.Blanchette Rockefeller Neurosciences InstituteRockvilleUSA
  4. 4.Section of Biochemistry & Mol. Biology, Department of ChemistryUniversity of CataniaCataniaItaly

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