Androgen Regulation of Lipogenesis

  • Johannes V. Swinnen
  • Hannelore Heemers
  • Walter Heyns
  • Guido Verhoeven
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


In several tissues and cell lines, including epithelial cells of the prostate, breast and seminal vesicles, and in acinar cells of the meibomian and other sebaceous glands, androgens have a major stimulatory effect on the production, accumulation and/or secretion of lipids.1–11 In most of these tissues and cell lines, the composition of these lipids is complex. Accumulating lipids include cholesterol esters, diacylglycerides, triglycerides and wax esters. Depending on the tissue type, these lipids may have different physiological functions and dysregulation of their production is related to pathological conditions as diverse as acne, dry eye syndromes and cancer. In acne and dry eye syndromes local modulation of androgen action may provide an effective therapy.7,12


Lacrimal Gland Alternative Reference Goblet Cell Density Tear Film Breakup Time Tear Film Stability 
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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Johannes V. Swinnen
    • 1
  • Hannelore Heemers
    • 1
  • Walter Heyns
    • 1
  • Guido Verhoeven
    • 1
  1. 1.Laboratory for Experimental Medicine and EndocrinologyK.U.LEUVEN, GasthuisbergLeuvenBelgium

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