Differential Expression of Adenylyl Cyclase mRNAs in Lacrimal Glands of NZB/NZW and NOD Pre-Autoimmune Mice
Sjögren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands. The disease is most prevalent in postmenopausal women who exhibit salivary and lacrimal insufficiencies resulting in dry mouth and dry eye. Diagnosis of SS is variously dependent upon the detection of anti-Ro (SS-A), anti-La (SS-B) and antinuclear (ANA) autoantibodies, as well as rheumatoid factor. Biopsies of the salivary and lacrimal glands of SS patients typically reveal periductal and perivascular lymphocytic infiltrates that are predominated by CD4+ T and B lymphocytes1–6. Emerging theories of the pathogenesis of SS postulate the disease proceeds in stages with the first stage characterized by an intrinsic failure of the secretory epithelial cells7–12. Successive stages include the autoimmune response in the lacrimal and salivary glands initiated by the target cells themselves. The final stage is seen as one in which immune-mediated destruction of the secretory architecture of the cell, as well as of the nerve fibers innervating the gland, occurs.
KeywordsOcular Surface Lacrimal Gland Conjunctival Epithelium Keratoconjunctivitis Sicca Conjunctival Epithelial Cell
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