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Differential Expression of Adenylyl Cyclase mRNAs in Lacrimal Glands of NZB/NZW and NOD Pre-Autoimmune Mice

  • Michele A. Meneray
  • Thomas E. Lallier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)

Abstract

Sjögren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands. The disease is most prevalent in postmenopausal women who exhibit salivary and lacrimal insufficiencies resulting in dry mouth and dry eye. Diagnosis of SS is variously dependent upon the detection of anti-Ro (SS-A), anti-La (SS-B) and antinuclear (ANA) autoantibodies, as well as rheumatoid factor. Biopsies of the salivary and lacrimal glands of SS patients typically reveal periductal and perivascular lymphocytic infiltrates that are predominated by CD4+ T and B lymphocytes1–6. Emerging theories of the pathogenesis of SS postulate the disease proceeds in stages with the first stage characterized by an intrinsic failure of the secretory epithelial cells7–12. Successive stages include the autoimmune response in the lacrimal and salivary glands initiated by the target cells themselves. The final stage is seen as one in which immune-mediated destruction of the secretory architecture of the cell, as well as of the nerve fibers innervating the gland, occurs.

Keywords

Ocular Surface Lacrimal Gland Conjunctival Epithelium Keratoconjunctivitis Sicca Conjunctival Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Michele A. Meneray
    • 1
  • Thomas E. Lallier
    • 2
  1. 1.Departments of PhysiologyLouisiana State University Health Sciences CenterNew OrleansUSA
  2. 2.Cell Biology and AnatomyLouisiana State University Health Sciences CenterNew OrleansUSA

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