Ocular TFF-Peptides: New Mucus-Associated Secretory Products of Conjunctival Goblet Cells

  • Gesa Langer
  • Wolfgang Jagla
  • Wolfgang Behrens-Baumann
  • Sven Walter
  • Werner Hoffmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


The ocular surface is overlaid by a three-layered tear film, 35–45 _m thick, that serves as a lubricant and protective barrier,1 and is essential for the normal function of the human eye. The outer lipid layer is secreted by the meibomian glands, and the intermediate aqueous layer is produced by the lacrimal glands. The inner layer of about 30 _m, contains mucins as its major structural components. These large glycoconjugates regulate the rheological properties defined by the tear breakup time of the ocular mucus. This parameter changes in the course of pathologic conditions such as dry eye disease.


Submandibular Gland Lacrimal Gland Secretory Function Congenic Mouse Chronic Autoimmune Disorder 
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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Gesa Langer
  • Wolfgang Jagla
    • 1
  • Wolfgang Behrens-Baumann
    • 2
  • Sven Walter
    • 2
  • Werner Hoffmann
    • 1
  1. 1.Institut für Molekularbiologie und Medizinische ChemieOtto-von-Guericke-UniversitätMagdeburgGermany
  2. 2.UniversitätsaugenklinikOtto-von-Guericke-UniversitätMagdeburgGermany

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