Abstract
The role of extracellular nucleotides as signaling molecules is well established in a number of biological systems. Their function in the regulation of ion1, 2 and fluid3 transport has been investigated in the pigmented rabbit conjunctiva where active Cl− secretion has been implicated as the driving force for fluid secretion.3 These agonists interact with two classes of receptors located on the cell membrane: P2X ligand-gated ion channels and P2Y G-protein-coupled receptors.4 Receptor mapping techniques have revealed the presence of P2Y type receptors in ocular epithelial cells.5
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© 2002 Kluwer Academic/Plenum Publishers
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Gukasyan, H.J., Yerxa, B.R., Pendergast, W., Lee, V.H.L. (2002). Metabolism and Transport of Purinergic Receptor Agonists in Rabbit Conjunctival Epithelial Cells. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_35
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_35
Publisher Name: Springer, Boston, MA
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