Epidermal Growth Factor Stimulates Fluid Transport in SV40 Transformed Rabbit Lacrimal Gland Cells

  • Pavel Iserovich
  • Maimaiti Yiming
  • Zheng Wang
  • Victor N. Bildin
  • Peter S. Reinach
  • Jorge Fischbarg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 506)


Lacrimal gland fluid secretion is essential for maintaining the aqueous volume of the precorneal tear film and ocular surface health. A decline in lacrimal gland fluid output can be a contributing factor to dry eye disease. Lacrimal gland functional activity is dependent on a host of neurohumors and cytokines that control its cells growth, differentiation and protein secretory activity. The release of one of these cytokines, epidermal growth factor (EGF), is regulated through neural control in the lacrimal gland.1–3 Furthermore, rat lacrimal acinar cells possess EGF receptors,4 suggesting that these cells respond to EGF. However, there have been no direct studies on the role of EGF in lacrimal gland fluid transport regulation.


Contact Lens Lacrimal Gland Serratia Marcescens Protein Deposition Lens Wearer 
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Copyright information

© Kluwer Academic/Plenum Publishers 2002

Authors and Affiliations

  • Pavel Iserovich
    • 1
  • Maimaiti Yiming
    • 1
  • Zheng Wang
    • 2
  • Victor N. Bildin
    • 2
  • Peter S. Reinach
    • 1
    • 2
  • Jorge Fischbarg
    • 1
  1. 1.Department of OphthalmologyColumbia UniversityNew YorkUSA
  2. 2.Dept. Biological Sciences, Coll. OptometrySUNYNew YorkUSA

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